Fluvastatin

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Fluvastatin
Systematic (IUPAC) name
7-[3-(4-fluorophenyl) -1-(1-methylethyl) -1H-indol-2-yl]-3, 5-dihydroxy-hept-6-enoic acid
Identifiers
CAS number	93957-54-1
ATC code	C10AA04
PubChem	1548972
DrugBank	APRD00346
Chemical data
Formula	C24H26FNO4
Mol. mass	411.466 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	98%
Metabolism	?
Half life	2.5 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Fluvastatin (Lescol, Canef) is a member of the drug class of statins, used to treat hypercholesterolemia and to prevent cardiovascular disease. It has also been shown to exhibit antiviral activity against Hepatitis C.^[1]

[edit] References

1. ^ Bader T, Fazili J, Madhoun M, et al (April 2008). "Fluvastatin Inhibits Hepatitis C Replication in Humans". Am. J. Gastroenterol.. doi:10.1111/j.1572-0241.2008.01876.x. PMID 18410471. 

v • d • e Lipid modifying agents (C10) Statins Atorvastatin • Cerivastatin‡ • Fluvastatin • Lovastatin • Mevastatin • Pitavastatin • Pravastatin • Rosuvastatin • Simvastatin Fibrates Clofibrate‡ • Bezafibrate • Aluminium clofibrate • Gemfibrozil • Fenofibrate • Simfibrate • Ronifibrate • Ciprofibrate • Etofibrate • Clofibride Bile acid sequestrants Colestyramine • Colestipol • Colextran • Colesevelam Niacin and derivatives Niceritrol • Niacin • Nicofuranose• Aluminium nicotinate• Nicotinyl alcohol • Acipimox CETP inhibitors Anacetrapib† • Torcetrapib§ Combinations Niacin/lovastatin • Niacin/simvastatin • Ezetimibe/simvastatin Other Dextrothyroxine • Probucol • Tiadenol • Benfluorex • Meglutol • Omega-3-triglycerides • Magnesium pyridoxal 5-phosphate glutamate • Policosanol • Ezetimibe • Laropiprant†, Lapaquistat§ †Undergoing clinical trials. ‡Withdrawn from market. §Development terminated.