Etofibrate

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Etofibrate
Systematic (IUPAC) name
2-{[2-(4-chlorophenoxy)-2-methylpropanoyl]oxy}ethyl nicotinate
Identifiers
CAS number 31637-97-5
ATC code C10AB09
PubChem 65777
Chemical data
Formula C18H18ClNO5 
Mol. mass 363.792 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism Hydrolyzed to clofibric acid and niacin
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Etofibrate is a fibrate. It is a combination of clofibrate and niacin, linked together by an ester bond. In the body, clofibrate and niacin separate and are released gradually, in a manner similar to controlled-release formulations.[1]

[edit] References

  1. ^ Sposito AC, Mansur AP, Maranhão RC, Rodrigues-Sobrinho CR, Coelho OR, Ramires JA (2001). "Etofibrate but not controlled-release niacin decreases LDL cholesterol and lipoprotein (a) in type IIb dyslipidemic subjects". Braz J Med Biol Res 34 (2): 177–82. PMID 11175492.  Free full text


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Lipid modifying agents (C10)
Statins
Fibrates
Bile acid sequestrants
Niacin and derivatives
CETP inhibitors
Combinations
Other
†Undergoing clinical trials. ‡Withdrawn from market. §Development terminated.