Fatty-acid synthase

From Wikipedia, the free encyclopedia

In enzymology, a fatty-acid synthase (EC 2.3.1.85) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H⁺ $\rightleftharpoons$ a long-chain fatty acid + (n⁺1) CoA + n CO₂ + 2n NADP⁺

The 4 substrates of this enzyme are acetyl-CoA, malonyl-CoA, NADPH, and H⁺, whereas its 4 products are long-chain fatty acid, CoA, CO₂, and NADP⁺.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing). This enzyme is also called yeast fatty acid synthase. This enzyme participates in fatty acid biosynthesis and insulin signaling pathway.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1N8L, 2CF2, 2CG5, 2JFD, 2JFK, 2PNG, and 2PX6.

[edit] References

IUBMB entry for 2.3.1.85
BRENDA references for 2.3.1.85 (Recommended.)
PubMed references for 2.3.1.85
PubMed Central references for 2.3.1.85
Google Scholar references for 2.3.1.85
Stoops JK, Ross P, Arslanian MJ, Aune KC, Wakil SJ, Oliver RM (1979). "Physicochemical studies of the rat liver and adipose fatty acid synthetases". J. Biol. Chem. 254: 7418–26. PMID 457689.
Wakil SJ, Stoops JK, Joshi VC (1983). "Fatty acid synthesis and its regulation". Annu. Rev. Biochem. 52: 537–79. PMID 6137188.