Brenner tumour
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| Brenner tumour Classification and external resources |
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| Brenner tumor of ovary | |
| ICD-9 | 220 |
| ICD-O: | 9000 |
| DiseasesDB | 33431 |
| MeSH | D001948 |
Brenner tumors are uncommon tumors that are part of the surface epithelial-stromal tumor group of ovarian neoplasms.
The majority of these tumors are benign. However, they can be malignant.[1]
They are most frequently found as incidental findings[2] on pelvic examination or at laparotomy.
Brenner tumors very rarely can occur in other locations, including testis.[3]
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[edit] Presentation
On gross pathological examination, they are solid, sharply circumscribed and pale yellow-tan in colour. 90% are unilateral (arising in one ovary, the other is unaffected). The tumors can vary in size from less than 1 cm to 30 cm. Borderline and malignant Brenner tumors are possible but each are rare.
Histologically, there are nests of transitional-type epithelial cells with longitudinal nuclear grooves (coffee bean nuclei) lying in abundant fibrous stroma.
[edit] Similar conditions
Transitional cell carcinoma is an even rarer entity, in which neoplastic transitional epithelial cells similar to transitional cell carcinoma of the bladder are seen in the ovary, without the characteristic stromal/epithelial pattern of a Brenner tumor.
[edit] Eponym
It is named for Fritz Brenner, who characterized it in 1907. [4] The term "Brenner tumor" was first used by Robert Meyer, in 1932.[5]
[edit] References
- ^ Marwah N, Mathur SK, Marwah S, Singh S, Karwasra RK, Arora B (2005). "Malignant Brenner tumour--a case report". Indian J Pathol Microbiol 48 (2): 251–2. PMID 16758686.
- ^ Green GE, Mortele KJ, Glickman JN, Benson CB (2006). "Brenner tumors of the ovary: sonographic and computed tomographic imaging features". J Ultrasound Med 25 (10): 1245–51; quiz 1252–4. PMID 16998096.
- ^ Caccamo D, Socias M, Truchet C (1991). "Malignant Brenner tumor of the testis and epididymis". Arch. Pathol. Lab. Med. 115 (5): 524–7. PMID 2021324.
- ^ Lamping JD, Blythe JG (1977). "Bilateral Brenner tumors: a case report and review of the literature". Hum. Pathol. 8 (5): 583–5. doi:. PMID 903146.
- ^ Philipp, Elliot Elias; O'Dowd, Michael J. (2000). The history of obstetrics and gynaecology. Carnforth, Lancs: Parthenon, 586. ISBN 1-85070-040-0.
[edit] External links
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