Talk:Atypical antipsychotic

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Contents 1 Melperone is an atypical antipsychotic? 2 Aripiprazole has no serotonergic action? 3 I slightly hope nobody will want this back. 4 Deletion of UK research ref Arch Gen Psych re comparative efficacy

[edit] Melperone is an atypical antipsychotic?

Melperone (Buronil, Eunerpan, Harmosin, Melneurin and other generic/trade names) is a typical sedative neuroleptic/antipsychotic, used for over 30 years in Europe now. Its only atypical propriety is, that it (and pipamperone/floropipamide, Dipiperon) is a butyrophenone derivative and is not a highly potent neuroleptic, such as other butyrophenone derivatives (haloperidol, benperidol, spiroperidol, trifluperidol, bromperidol or moperone). It causes quite little EPMS, but so does e.g. thioridazine and is not classified an atypical antipsychotic. Melperone is low-potency, sedative, 1st generation butyrophenone antipsychotic.--Spiperon 21:47, 3 May 2007 (UTC)

[edit] Aripiprazole has no serotonergic action?

Aripiprazole (Abilify) acts as a partial agonist at the 5-HT1A receptor, and as an antagonist at 5-HT2A. I'd say that's serotonergic activity. --KaterGator 20:22, 24 August 2007 (CST)

[edit] I slightly hope nobody will want this back.

"More recent research is questioning the notion that second generation anti-psychotics are superior to first generation typical anti-psychotics. Using a number of parameters to assess quality of life University of Manchester researchers found that typical anti-psychotics were no worse than atypical anti-psychotics. The research was funded by the National Health Scheme of the UK.[1]"

Everything under, including risperidone had given me pains impossible to explain. It equates to continuous physical torture. Well I'm intelligent and particularly sensitive in nervous reaction, but the damage was equal to that of the mountain shepherd boy, with the difference that he was too stall to tell. He does not need the psychological functions that are disabled by the old medication and he has a higher thresh hold of pain, so he seems OK. Normal people feel just dizzy, they do not now the length at which their superior processes are disturbed by the old medication. In general there can be no intellectual recovery by using the old medication. Proper social involvement does require the processes that are disabled by them. Quality of life can not be measured good enough by people who measure contentedness with non-activity. The damage is taken. The parameters are subjective. My incapacity was totally there, a billion crisp shades of unknown pain and disabilities, including the one to convince the doctor the faint complain for the pain is your last and maximum strength, not a usual psycho-paranoid complaint against medicine and signature on documents. GOD I hate them, theory and lab doctors. Rats. Whores. Demented messengers of authority and current overwhelming empirical evidence.

So I just hope... . Watiki 15:58, 4 September 2007 (UTC)

[edit] Deletion of UK research ref Arch Gen Psych re comparative efficacy

Material relating to UK research about comparative efficacy of older agents has been restored after previous deletion on the basis that the person causing the deletion has had unpleasant experiences with atypical antipsychotics and hates lab doctors. The reasons stated are personal and unscientific and do not justify erasing this important research which is tending to question superiority of newer agents.