Talk:Xeroderma pigmentosum

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To-do list for Xeroderma pigmentosum: edit · history · watch · refresh

Strike through when completed

  • Add references section
  • Expand 8 types of XP section
  • Role of XPB helicase (belongs to Nucleotide excision repair)
  • Illustration of mutation (what a bullshit, sorry)
  • Discussion of how rare it is, and distribution worldwide
  • table that lists the cancer frequencies in the different kind of XP-groups

Contents

[edit] correction, and addition

The DNA is actually excised by endonucleases, not exonucleases. I'm not going to change it because I don't have a specific reference confirming it. Exonucleases actually remove from the ends of DNA strands, whereas endonucleases cut phosphodiester bonds inside DNA strands (which is what is needed for excision). In prokaryotes, the mechanism for this excision repair is that the uvrABCendonuclease nicks the DNA strand on either side of the pyrimidine dimer, and a specialized helicase (not the same helicase that participates in replication) breaks the Hydrogen bonds holding the nicked portion to the other strand. DNA Polymerase then replaces the nucleotides starting at the 3' end of the excision. Ligase connects the final phosphodiester bond and completes the repair. XP is a result from mutation of the helicase, or one of the uvr genes. I've been told that the mechanism is nearly identical in eukaryotes (the names of the endonuclease is different I believe).

[edit] Comment

this disease would suck —Preceding unsigned comment added by 164.68.181.1 (talk • contribs)

[edit] Symptoms?

Why are no symptoms found on this page? Sure, skin cancer... but that's not the only symptom. Do people with XP have any reactions to sunlight like burning of the skin, getting dizzy, etc? Surely there must be a source somewhere that gives some actual useful information to the common, everyday person. Vancar 16:43, 7 July 2006 (UTC)

And article should mention about not being able to watch television, sit in front of computer monitors? Tempshill 04:43, 7 September 2006 (UTC)

[edit] Merge

I don't think the merger makes very much sense; presumably the enzyme is involved in more than this disease. -- Visviva 07:28, 30 July 2006 (UTC)

I agree, Against merge. According to the XPB page, this isn't the only disorder that can arise from it... thence, it can't be merged to this page alone. 24.126.199.129 08:48, 23 August 2006 (UTC)

[edit] Redirect?

Why is there a redirect from Sun Allergy to this page? 83.70.41.4 10:55, 16 September 2006 (UTC)

I've moved it to Rash --apers0n 12:34, 16 September 2006 (UTC)