Talk:Wolff-Chaikoff effect

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[edit] Jodbasedow phenomenon

I believe what you describe is the Jodbasedow phenomenon. The Wolff-Chaikoff effect is the normal inhibition of iodine organification and hormone formation once the maximum level has been reached. It is the "shut-off switch" for the system. With the Jodbasedow phenomenon, the shutoff is not working and iodine continues to be transported across the membrane, organified and hormone made, resulting in an iodine-induced hypothyroidism.

--Name8318 02:37, 20 July 2007 (UTC)

Suggest this reference should be considered.

Plasma Inorganic Iodide as a Homeostatic Regulator of Thyroid Function.

J. Biol. Chem. Wolff and Chaikoff 174 (2): 555

The paper is available for free download.

http://www.jbc.org/cgi/reprint/174/2/555 —Preceding unsigned comment added by 84.45.158.52 (talk) 23:19, 10 January 2008 (UTC)