Vellosimine dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a vellosimine dehydrogenase (EC 1.1.1.273) is an enzyme that catalyzes the chemical reaction

10-deoxysarpagine + NADP⁺ vellosimine + NADPH + H⁺

Thus, the two substrates of this enzyme are 10-deoxysarpagine and NADP⁺, whereas its 3 products are vellosimine, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 10-deoxysarpagine:NADP+ oxidoreductase. This enzyme participates in indole and ipecac alkaloid biosynthesis.

[edit] References

• IUBMB entry for 1.1.1.273
• BRENDA references for 1.1.1.273 (Recommended.)
• PubMed references for 1.1.1.273
• PubMed Central references for 1.1.1.273
• Google Scholar references for 1.1.1.273
• Pfitzner A, Krausch B and Stockigt J (1984). "Characteristics of vellosimine reductase, a specific enzyme involved in the biosynthesis of the Rauwolfia alkaloid sarpagine". Tetrahedron 40: 1691–1699. doi:10.1016/S0040-4020(01)91118-4. 

[edit] External links

The CAS registry number for this enzyme class is 86777-26-6.

• IUBMB entry for 1.1.1.273

• KEGG entry for 1.1.1.273

• BRENDA entry for 1.1.1.273

• NiceZyme view of 1.1.1.273

• EC2PDB: PDB structures for 1.1.1.273

• PRIAM entry for 1.1.1.273

• PUMA2 entry for 1.1.1.273

• IntEnz: Integrated Enzyme entry for 1.1.1.273

• MetaCyc entry for 1.1.1.273

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050579: vellosimine dehydrogenase

• AMIGO entry for GO code 0050579: vellosimine dehydrogenase