Ureidoglycolate dehydrogenase

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In enzymology, an ureidoglycolate dehydrogenase (EC 1.1.1.154) is an enzyme that catalyzes the chemical reaction

(S)-ureidoglycolate + NAD(P)+ oxalureate + NAD(P)H + H⁺

The 3 substrates of this enzyme are (S)-ureidoglycolate, NAD⁺, and NADP⁺, whereas its 4 products are oxalureate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-ureidoglycolate:NAD(P)+ oxidoreductase. This enzyme participates in purine metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1WTJ and 1XRH.

[edit] References

• IUBMB entry for 1.1.1.154
• BRENDA references for 1.1.1.154 (Recommended.)
• PubMed references for 1.1.1.154
• PubMed Central references for 1.1.1.154
• Google Scholar references for 1.1.1.154
• van der Drift C, van Helvoort PE, Vogels GD (1971). "S-ureidoglycolate dehydrogenase: purification and properties". Arch. Biochem. Biophys. 145: 465–9. doi:10.1016/S0003-9861(71)80006-1. PMID 4399430. 

[edit] External links

The CAS registry number for this enzyme class is 62213-62-1.

• IUBMB entry for 1.1.1.154

• KEGG entry for 1.1.1.154

• BRENDA entry for 1.1.1.154

• NiceZyme view of 1.1.1.154

• EC2PDB: PDB structures for 1.1.1.154

• PRIAM entry for 1.1.1.154

• PUMA2 entry for 1.1.1.154

• IntEnz: Integrated Enzyme entry for 1.1.1.154

• MetaCyc entry for 1.1.1.154

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0009040: ureidoglycolate dehydrogenase

• AMIGO entry for GO code 0009040: ureidoglycolate dehydrogenase