Troponin C

From Wikipedia, the free encyclopedia

Troponin C is a part of the troponin complex. It contains four calcium-binding EF hands. It contains an N lobe and a C lobe. The C lobe serves a structural purpose and binds to the N domain of TnI. The C lobe can bind either Ca2+ or Mg2+. The N lobe, which binds only Ca2+, is the regulatory lobe and binds to the C domain of TnI after calcium binding.

The tissue specific subtypes are:

• Slow troponin C, TNNC1 (3p21.3-p14.3, Online 'Mendelian Inheritance in Man' (OMIM) 191040)
• Fast troponin C, TNNC2 (20q12-q13.11, 2191039

[edit] See also

• Calcium-binding protein

[edit] External links

• MeSH Troponin+C

v • d • e Histology: muscle tissue skeletal muscle/general epimysium, fascicle, perimysium, endomysium, muscle fiber (intrafusal, extrafusal), myofibril sarcomere (a, i, and h bands; z and m lines), myofilaments (thin filament/actin, thick filament/myosin, elastic filament/titin, nebulin), tropomyosin, troponin (T, C, I) costamere (dystrophin, α,β-dystrobrevin, syncoilin, synemin/desmuslin, dysbindin, sarcoglycan, dystroglycan, sarcospan), desmin neuromuscular junction, motor unit, muscle spindle, excitation-contraction coupling, sliding filament mechanism myoblast, satellite cell, sarcoplasm, sarcolemma, sarcoplasmic reticulum, T-tubule cardiac muscle myocardium, intercalated disc, nebulette smooth muscle calmodulin, vascular smooth muscle

v • d • e Proteins of the cytoskeleton Microfilaments Actins - Actin-binding proteins - Actinin - Arp2/3 complex - Cofilin - Destrin - Gelsolin - Myosins - Profilin - Tropomodulin - Troponin (T, C, I) - Tropomyosin - Wiskott-Aldrich syndrome protein Intermediate filaments type 1 and 2 (Cytokeratin, type I, type II) - type 3 (Desmin, GFAP, Peripherin, Vimentin) - type 4 (Internexin, Nestin, Neurofilament, Synemin, Syncoilin) - type 5 (Lamin A, B) Microtubules Dyneins - Kinesins - MAPs (Tau protein, Dynamin) - Tubulins - Stathmin - Tektin Catenins Alpha catenin - Beta catenin - Plakoglobin (gamma catenin) - Delta catenin Nonhuman Major sperm proteins - Prokaryotic cytoskeleton (Crescentin, FtsZ, MreB) Other APC - Dystrophin (Dystroglycan) - plakin (Desmoplakin, Plectin) - Spectrin - Talin - Utrophin - Vinculin

v • d • e Carrier protein: calcium-binding proteins Intracellular calcium-sensing proteins Calmodulin - Calnexin - Calreticulin - Gelsolin - neuronal (Hippocalcin, Neurocalcin, Recoverin) Other Annexin (A1, A2, A5) - Vitamin D-dependent calcium-binding protein/Calbindin - Calexcitin - Calsequestrin - Fibulin - Matrix gla protein - Osteocalcin - Osteonectin - S-100 - Synaptotagmin - Troponin C