Hippocalcin

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hippocalcin
Identifiers
Symbol	HPCA
Entrez	3208
HUGO	5144
OMIM	142622
RefSeq	NM_002143
UniProt	P84074
Other data
Locus	Chr. 1 p35-p34.2

Hippocalcin (HPCA) is a calcium-binding protein that belongs to neuronal calcium sensor (NCS) family of proteins. It expressed in mammalian brains especially in the hippocampus. It possesses a Ca²⁺/myristoyl switch.

It takes part in the following prosesses:

• Activation of PLD and PLD2 expression

• Inhibition of apoptosis

• MAP kinase signalling

• Involved in long term depression in hippocampal neuron

• Required for normal spatial learning

It interacts with following proteins:

• Neuronal apoptosis inhibitory protein (NAIP)

• Mixed lineage kinase 2 (MLK2)MLK2 is myosin light chain kinase 2

• The b2 adaptin of the AP2 complex

• Calcium-dependent activator protein for secretion (CAPS)

v • d • e Carrier protein: calcium-binding proteins Intracellular calcium-sensing proteins Calmodulin - Calnexin - Calreticulin - Gelsolin - neuronal (Hippocalcin, Neurocalcin, Recoverin) Other Annexin (A1, A2, A5) - Vitamin D-dependent calcium-binding protein/Calbindin - Calexcitin - Calsequestrin - Fibulin - Matrix gla protein - Osteocalcin - Osteonectin - S-100 - Synaptotagmin - Troponin C