Tropinone reductase I

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In enzymology, a tropinone reductase I (EC 1.1.1.206) is an enzyme that catalyzes the chemical reaction

tropine + NADP⁺ $\rightleftharpoons$ tropinone + NADPH + H⁺

Thus, the two substrates of this enzyme are tropine and NADP⁺, whereas its 3 products are tropinone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is tropine:NADP+ 3alpha-oxidoreductase. Other names in common use include tropine dehydrogenase, tropinone reductase (ambiguous), and TR-I. This enzyme participates in alkaloid biosynthesis ii.

[edit] References

IUBMB entry for 1.1.1.206
BRENDA references for 1.1.1.206 (Recommended.)
PubMed references for 1.1.1.206
PubMed Central references for 1.1.1.206
Google Scholar references for 1.1.1.206
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Couladis MM, Friesen JB, Landgrebe ME and Leete E (1991). "Enzymes catalysing the reduction of tropinone to tropine and ψ-tropine isolated from the roots of Datura innoxia". Pytochemistry 30: 801–805. doi:10.1016/0031-9422(91)85255-X.
Nakajima K, Hashimoto T, Yamada Y (1993). "Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor". Proc. Natl. Acad. Sci. U. S. A. 90: 9591–5. doi:10.1073/pnas.90.20.9591. PMID 8415746.
Drager B (2006). "Tropinone reductases, enzymes at the branch point of tropane alkaloid metabolism". Phytochemistry. 67: 327–37. doi:10.1016/j.phytochem.2005.12.001. PMID 16426652.