Trimethylamine-N-oxide reductase

From Wikipedia, the free encyclopedia

In enzymology, a trimethylamine-N-oxide reductase (EC 1.6.6.9) is an enzyme that catalyzes the chemical reaction

NADH + H⁺ + trimethylamine N-oxide NAD⁺ + trimethylamine + H₂O

The 3 substrates of this enzyme are NADH, H⁺, and trimethylamine N-oxide, whereas its 3 products are NAD⁺, trimethylamine, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with a nitrogenous group as acceptor. The systematic name of this enzyme class is NADH:trimethylamine-N-oxide oxidoreductase. Other names in common use include trimethylamine N-oxide reductase, trimethylamine oxide reductase, TMAO reductase, and TOR. This enzyme participates in methane metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1TMO.

[edit] References

• IUBMB entry for 1.6.6.9
• BRENDA references for 1.6.6.9 (Recommended.)
• PubMed references for 1.6.6.9
• PubMed Central references for 1.6.6.9
• Google Scholar references for 1.6.6.9
• Unemoto T, Hayashi M, Miyaki K, Hayashi M (1965). "Intracellular localization and properties of trimethylamine-N-oxide reductase in Vibrio parahaemolyticus". Biochim. Biophys. Acta. 110: 319–28. PMID 4286289. 

[edit] External links

The CAS registry number for this enzyme class is 37256-34-1.

• IUBMB entry for 1.6.6.9

• KEGG entry for 1.6.6.9

• BRENDA entry for 1.6.6.9

• NiceZyme view of 1.6.6.9

• EC2PDB: PDB structures for 1.6.6.9

• PRIAM entry for 1.6.6.9

• PUMA2 entry for 1.6.6.9

• IntEnz: Integrated Enzyme entry for 1.6.6.9

• MetaCyc entry for 1.6.6.9

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0009033: trimethylamine-N-oxide reductase

• AMIGO entry for GO code 0009033: trimethylamine-N-oxide reductase