Talk:Tricyclic antidepressant
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My understanding was that it was an early MAOI, which was being used to treat tuberculosis, that was found to make patients euphoric. Anyone have a source? RoseParks
I think you might be right. Deleted the reference.
What does the word "quinidineline" (referenced in the article as a type of side effect) mean? I've tried googling for it and the word yielded about 130 matches, most of which want to give me "free" ringtones and poker games. I'm at a loss. --65.114.61.232 21:01, 27 June 2006 (UTC)
This is the first type of drug mentioned in the article Appetite enhancers yet the appetite enhancing properties are given as a side effect in this article with less than a sentence devoted to them. No criticism intended, just a reader who was interested in seeing more on a specific topic 81.146.65.109 23:01, 2 January 2007 (UTC)
What does the word "quinidineline" (referenced in the article as a type of side effect) mean? I've tried googling for it and the word yielded about 130 matches, most of which want to give me "free" ringtones and poker games. I'm at a loss. --65.114.61.232 21:01, 27 June 2006 (UTC)
I am a pharmacy tech student and I looked up quinidineline in the mosby's drug consult it is another drug that can be used and has the same effects as the tricyclic antidepressant to which you were looking at. If that is any help...(24.230.39.40 00:09, 11 February 2007 (UTC))
Perhaps a reference to the risk of induction of mania would be useful. Dixon pete 22:13, 10 May 2007 (UTC)
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[edit] Difference between this and SSRIs
What would the main differences between this and SSRIs, if anyone has the knowledge? I know that MAOIs are used as a last choice, but I'm unsure why these types are being replaced, and the outstanding features of SSRIs which make this the predecessor. Daily Rubbings 03:35, 19 May 2007 (UTC)
- Generally SSRI's replaced the TCA's because of the latter's side effects (dry mouth, drowsiness, blurred vision etc). Although subsequent random controlled studies have suggested that the difference in tolerability is not as much as commonly assumed. Also TCA's more toxic in overdosage, and so SSRIs safer to initiate in depressed patients (i.e. safer in over dosage - recognising that despite some concerns for increased tendency to attempt suicide on starting treatment, this is small compared to far larger rates of suicide from the non-treated or under-treated condition itself). That said, the less sedating TCAs eg lofepramine still have a role. The TCAs have a much greater effectiveness in low-dosages (especially amitriptyline) as pain moidifiers and migraine/headache preventers (Fluoxetine perhaps just 30% as effective according to one consultant I spoke to - but that of course does not constitute a reliable encyclopaedia source) David Ruben Talk 11:43, 19 May 2007 (UTC)
[edit] Tricyclic Antidepressants and THC
I was once prescribed tofranil when I was about 14 years old. I had stopped smoking marijuana during the month I was taking tofranil. When I began smoking again I would have hallucinations on extremely low doses of THC. Only one small puff of the lowest grade marijuana would make me experience profound and overwhelming euphoria and hallucinations. Is this just for my case? Although these experiences may be too intense for most, I thought it was great, especially due to the fact my therapist prescribed me these for depression and marijuana use. It just seems silly to give me a drug that exponentially increases the effects of a drug I was having problems stopping.
[edit] Selectivity
I tried to confirm the table from other sources available on the net, but every source I dug up puts a slightly different spin on things. I ended up referencing only the source that put matters in numerical terms based on recent radioligand surveys, which seemed most authoritative, but also incomplete. If my material on secondary and tertiary amine classification is retained, it would probably be better placed in the table, but I didn't wish to mess (too much) with the MeSH claim. I did add one TCA that wasn't mentioned.
In general, it is problematic to determine whether drugs are being classified, or individual metabolites. MaxEnt 09:37, 11 October 2007 (UTC)
[edit] History
I added a chunk on the development history. The two useful sources I found were hard to mesh, and one would given a person and a time, and the other a corporation and a place, but not so as you could confidently match one to the other in declarative sentences. I intended to unearth the key patents. Google is quick to pull up an expensive source which I don't have access to. Using the free patent search I was able to get close, but was hampered by the lack of fully electronic forward/backward references in patents prior to 1976. I searched one chain backwards by hand and thought I had it (the patent for amitrip), but then I noticed it was the wrong firm. Perhaps Smith Kline licensed to Merck. I can't find any TCA introduced by Smith Kline, yet they seem to hold a patent that almost exactly describes amitrip and in roughly the right time period (plus/minus my amateur chemistry). MaxEnt 11:52, 12 October 2007 (UTC)
[edit] Histamine
"Although norepinephrine and dopamine are generally considered stimulatory neurotransmitters, tricyclic antidepressants also increase the effects H1 histamine, and thus most have sedative effects.[5]"
Makes no sense. Histamine H1 antagonists according to the wikipedia article make people sleepy - anti-histamines. Thats why allergy medication is advertised as non-drowsy these days. Perhaps it means to say "tricyclic antidepressants also decrease the effects of H1 histamine"? Would also make sense since it says it is a H1 ANTagonist. 81.104.186.166 14:46, 2 December 2007 (UTC)
