Talk:Transthyretin
From Wikipedia, the free encyclopedia
 |
This article is within the scope of the Molecular and Cellular Biology WikiProject. To participate, visit the WikiProject for more information. The WikiProject's current monthly collaboration is focused on improving Restriction enzyme. | ||
|
Article Grading: The article has not been rated for quality and/or importance yet. Please rate the article and then leave comments here to explain the ratings and/or to identify the strengths and weaknesses of the article. Click here for an overview of how to rate this article. |
|||
[edit] Low CSF transthyretin in schizophrenia
Low concentration of three peptide fragments of transthyretin in the cerebrospinal fluid has been recently found in schizophrenic patients:
--CopperKettle 10:48, 3 December 2006 (UTC)
[edit] Whole issue of a journal devoted to transthyretin
There's an year 2002 Issue 12 of "Clinical chemistry and laboratory medicine" devoted mainly to transthyretin. A person with an access could get much information there concerning the history of this protein etc. Would be nice to have a "history" section (discovery, evolution of the protein and so on). CopperKettle 09:10, 19 December 2006 (UTC)
[edit] Vitamin-K Dependent? Evidence of post-translational carboxylation
I just found this. Does this mean that vitamin K is implicated in proper functioning of transthyretic and therefore could have something to do with hypothyroidism?
- Protein Pept Lett. 2008;15(1):43-6.
Detection of a gamma-carboxy-glutamate as novel post-translational modification of human transthyretin.
Rüggeberg S, Horn P, Li X, Vajkoczy P, Franz T. European Molecular Biology Laboratory, Proteomic Core Facility, Meyerhofstr. 1. 69117 Heidelberg, Germany.
During analysis of the proteome in the cerebrospinal fluid (CSF) of the Caucasian form of moyamoya disease (MMD), a novel post-translational modification of human transthyretin was observed. Two-dimensional electrophoresis and subsequent peptide sequencing with ESI-MS/MS were performed to discover the gamma-carboxylation of the Glu-42 (Gla-42). [PMID 18221012] —Preceding unsigned comment added by 216.9.143.32 (talk) 19:08, 12 May 2008 (UTC)
