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Contents 1 narrowing the definition of transmissible 2 Renaming 2.1 Result 3 All TSEs are transmissible 3.1 What was your first clue? 3.2 Prion peer review 3.3 Alper's disease 3.4 Sources 3.5 Prion of bacterial disease?

[edit] narrowing the definition of transmissible

I understand that the "transmissible" in TSE stands for "transmissible between individuals". As such, some of the listed disease are not TSEs, even though they are caused by prions. Examples are [normal or spontaneous] CJD and FFI. These arise from spontaneous changes in protein conformation in individuals. It might be argued that they might be transmissable if infectious material was injected into the brain of another animal, but to my knowledge, this has not been done.

Does someone have source for the usage of transmissible in this context?

Is it indeed 'able to be transmitted'? if so, this could expanded upon.

[edit] Renaming

I agree with the comment above, and I think this page should be renamed to "Spongiform encephalopathy". For example, Fatal familial insomnia seems to be inherited. Are there any objections to this renaming? --Arcadian 20:20, 7 December 2005 (UTC)

While that name might be more correct, I think transmissible spongiform encephalopathy is the most commonly used name in medical literature (8885 vs. 1382 hits for a pubmed search), so I would say don't move it. (btw. all human TSEs can occur three ways: sporadically; as hereditary diseases; or through transmission from infected individuals) --WS 17:31, 17 December 2005 (UTC)

[edit] Result

It was requested that this article be renamed but there was no consensus for it to be moved. WhiteNight ^{T | @ | C} 21:22, 29 December 2005 (UTC)

[1]: Even if you're familiar with the subject or think you know what it literally means, one word encephalopathy covers a lot of territory. Spongiform might even be redundant for being typical, although I doubt it in the case of Parkinson's.

BTW, I made a large number of edits that you might have seen coming only if you had noticed my contributions to the page on prions under discussion [2]here or [3]here. 216.234.170.74 10:18, 31 July 2006 (UTC)

[edit] All TSEs are transmissible

[edit] What was your first clue?

I move that the redirect from Spongiform Encephalopathy to "Transmissible SE" be removed. Pathology where the case is not transmissible or infectious is bound to exist. Brewhaha@edmc.net 03:36, 21 March 2007 (UTC)

[edit] Prion peer review

I've nominated the prion article for peer review, any comments welcome here! --Purple 02:49, 11 March 2006 (UTC)

[edit] Alper's disease

If someone finds more information about Alper's disease, it would be nice to have it in Wikipedia. If Alper's disease really is a TSE, it would be remarkable. All other hereditary TSE:s are dominant mutations of the PrP gene. Alper's disease is caused by a resessive mutation of some other unknown gene.

[edit] Sources

[4]: I wonder how things have changed when Nature in this article on the protein-only hypothesis implies that In Vitro (with dead objects) is the standard for proof. It might be useful in leading to ex vivo (was alive) demonstration of the cause, and last time I read anything about it, that could be ingestion of incinerated remains of an affected host, something that probably precludes anything but elements as a cause. 216.234.170.74 16:17, 31 July 2006 (UTC)

[edit] Prion of bacterial disease?

Apparently prion hypothesis is not the only one to explain the condition. They may be responsible for a part of the cases, but some cases of the disease can be induced by Spiroplasma infection [5], thus prions have no role in them. Thus, the definition should be corrected to add bacteria as one of the possible infectious agents besides prions.--Oleksii0 (talk) 22:17, 10 February 2008 (UTC)