Tight junction protein 2

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Tight junction protein 2 (zona occludens 2)
PDB rendering based on 2csj.
Available structures: 2csj
Identifiers
Symbol(s) TJP2; MGC26306; X104; ZO-2; ZO2
External IDs OMIM: 607709 MGI: 1341872 HomoloGene: 3541
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9414 21873
Ensembl ENSG00000119139 ENSMUSG00000024812
Uniprot Q9UDY2 Q9Z0U1
Refseq NM_004817 (mRNA)
NP_004808 (protein)		 NM_011597 (mRNA)
NP_035727 (protein)
Location Chr 9: 70.96 - 71.06 Mb Chr 19: 24.16 - 24.29 Mb
Pubmed search [1] [2]

Tight junction protein 2 (zona occludens 2), also known as TJP2, is a human gene.

Tight junction proteins (TJPs) belong to a family of membrane-associated guanylate kinase (MAGUK) homologs that are involved in the organization of epithelial and endothelial intercellular junctions. TJPs bind to the cytoplasmic C termini of junctional transmembrane proteins and link them to the actin cytoskeleton.[supplied by OMIM][1]

[edit] References

  1. ^ Entrez Gene: TJP2 tight junction protein 2 (zona occludens 2).

[edit] Further reading

  • Denker BM, Nigam SK (1998). "Molecular structure and assembly of the tight junction.". Am. J. Physiol. 274 (1 Pt 2): F1–9. PMID 9458817. 
  • González-Mariscal L, Betanzos A, Avila-Flores A (2000). "MAGUK proteins: structure and role in the tight junction.". Semin. Cell Dev. Biol. 11 (4): 315–24. doi:10.1006/scdb.2000.0178. PMID 10966866. 
  • King JE, Eugenin EA, Buckner CM, Berman JW (2006). "HIV tat and neurotoxicity.". Microbes Infect. 8 (5): 1347–57. doi:10.1016/j.micinf.2005.11.014. PMID 16697675. 
  • Van Itallie CM, Balda MS, Anderson JM (1995). "Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells.". J. Cell. Sci. 108 ( Pt 4): 1735–42. PMID 7542259. 
  • Duclos F, Rodius F, Wrogemann K, et al. (1994). "The Friedreich ataxia region: characterization of two novel genes and reduction of the critical region to 300 kb.". Hum. Mol. Genet. 3 (6): 909–14. PMID 7951235. 
  • Beatch M, Jesaitis LA, Gallin WJ, et al. (1996). "The tight junction protein ZO-2 contains three PDZ (PSD-95/Discs-Large/ZO-1) domains and an alternatively spliced region.". J. Biol. Chem. 271 (42): 25723–6. PMID 8824195. 
  • Itoh M, Morita K, Tsukita S (1999). "Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin.". J. Biol. Chem. 274 (9): 5981–6. PMID 10026224. 
  • Chlenski A, Ketels KV, Tsao MS, et al. (1999). "Tight junction protein ZO-2 is differentially expressed in normal pancreatic ducts compared to human pancreatic adenocarcinoma.". Int. J. Cancer 82 (1): 137–44. PMID 10360833. 
  • Chlenski A, Ketels KV, Engeriser JL, et al. (1999). "zo-2 gene alternative promoters in normal and neoplastic human pancreatic duct cells.". Int. J. Cancer 83 (3): 349–58. PMID 10495427. 
  • Wittchen ES, Haskins J, Stevenson BR (2000). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3.". J. Biol. Chem. 274 (49): 35179–85. PMID 10575001. 
  • Itoh M, Furuse M, Morita K, et al. (2000). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins.". J. Cell Biol. 147 (6): 1351–63. PMID 10601346. 
  • Cordenonsi M, D'Atri F, Hammar E, et al. (2000). "Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin.". J. Cell Biol. 147 (7): 1569–82. PMID 10613913. 
  • Mattagajasingh SN, Huang SC, Hartenstein JS, Benz EJ (2000). "Characterization of the interaction between protein 4.1R and ZO-2. A possible link between the tight junction and the actin cytoskeleton.". J. Biol. Chem. 275 (39): 30573–85. doi:10.1074/jbc.M004578200. PMID 10874042. 
  • Chlenski A, Ketels KV, Korovaitseva GI, et al. (2000). "Organization and expression of the human zo-2 gene (tjp-2) in normal and neoplastic tissues.". Biochim. Biophys. Acta 1493 (3): 319–24. PMID 11018256. 
  • Citi S, D'Atri F, Parry DA (2000). "Human and Xenopus cingulin share a modular organization of the coiled-coil rod domain: predictions for intra- and intermolecular assembly.". J. Struct. Biol. 131 (2): 135–45. doi:10.1006/jsbi.2000.4284. PMID 11042084. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863. 
  • Glaunsinger BA, Weiss RS, Lee SS, Javier R (2001). "Link of the unique oncogenic properties of adenovirus type 9 E4-ORF1 to a select interaction with the candidate tumor suppressor protein ZO-2.". EMBO J. 20 (20): 5578–86. doi:10.1093/emboj/20.20.5578. PMID 11598001. 
  • Islas S, Vega J, Ponce L, González-Mariscal L (2002). "Nuclear localization of the tight junction protein ZO-2 in epithelial cells.". Exp. Cell Res. 274 (1): 138–48. doi:10.1006/excr.2001.5457. PMID 11855865. 
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