Tight junction protein 1

From Wikipedia, the free encyclopedia

Tight junction protein 1 (zona occludens 1)

PDB rendering based on 2h2b.

Available structures: 2h2b, 2h2c, 2h3m

Identifiers

Symbol(s)

TJP1; DKFZp686M05161; MGC133289; ZO-1

External IDs

OMIM: 601009 MGI: 98759 HomoloGene: 2445

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• membrane fraction • nucleus • plasma membrane • septate junction • tight junction • intercellular canaliculus
Biological Process:	• intercellular junction assembly

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003257 (mRNA)
NP_003248 (protein)

NM_009386 (mRNA)
NP_033412 (protein)

Location

Chr 15: 27.78 - 27.9 Mb

Chr 7: 65.18 - 65.25 Mb

Pubmed search

[1]

[2]

Tight junction protein 1 (zona occludens 1), also known as TJP1, is a human gene.

This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for this gene.^[1]

[edit] See also

Tight junction

[edit] References

^ Entrez Gene: TJP1 tight junction protein 1 (zona occludens 1).

[edit] Further reading

González-Mariscal L, Betanzos A, Avila-Flores A (2000). "MAGUK proteins: structure and role in the tight junction.". Semin. Cell Dev. Biol. 11 (4): 315–24. doi:10.1006/scdb.2000.0178. PMID 10966866.
Anderson NL, Anderson NG (2003). "The human plasma proteome: history, character, and diagnostic prospects.". Mol. Cell Proteomics 1 (11): 845–67. PMID 12488461.
Willott E, Balda MS, Heintzelman M, et al. (1992). "Localization and differential expression of two isoforms of the tight junction protein ZO-1.". Am. J. Physiol. 262 (5 Pt 1): C1119–24. PMID 1590354.
Van Itallie CM, Balda MS, Anderson JM (1995). "Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells.". J. Cell. Sci. 108 ( Pt 4): 1735–42. PMID 7542259.
Balda MS, Anderson JM (1993). "Two classes of tight junctions are revealed by ZO-1 isoforms.". Am. J. Physiol. 264 (4 Pt 1): C918–24. PMID 7682777.
Furuse M, Itoh M, Hirase T, et al. (1995). "Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.". J. Cell Biol. 127 (6 Pt 1): 1617–26. PMID 7798316.
Willott E, Balda MS, Fanning AS, et al. (1993). "The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.". Proc. Natl. Acad. Sci. U.S.A. 90 (16): 7834–8. PMID 8395056.
Itoh M, Nagafuchi A, Yonemura S, et al. (1993). "The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy.". J. Cell Biol. 121 (3): 491–502. PMID 8486731.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Mohandas TK, Chen XN, Rowe LB, et al. (1997). "Localization of the tight junction protein gene TJP1 to human chromosome 15q13, distal to the Prader-Willi/Angelman region, and to mouse chromosome 7.". Genomics 30 (3): 594–7. doi:10.1006/geno.1995.1281. PMID 8825647.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Itoh M, Nagafuchi A, Moroi S, Tsukita S (1997). "Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to alpha catenin and actin filaments.". J. Cell Biol. 138 (1): 181–92. PMID 9214391.
Haskins J, Gu L, Wittchen ES, et al. (1998). "ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin.". J. Cell Biol. 141 (1): 199–208. PMID 9531559.
Moroi S, Saitou M, Fujimoto K, et al. (1998). "Occludin is concentrated at tight junctions of mouse/rat but not human/guinea pig Sertoli cells in testes.". Am. J. Physiol. 274 (6 Pt 1): C1708–17. PMID 9611137.
Giepmans BN, Moolenaar WH (1998). "The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein.". Curr. Biol. 8 (16): 931–4. PMID 9707407.
Katsube T, Takahisa M, Ueda R, et al. (1998). "Cortactin associates with the cell-cell junction protein ZO-1 in both Drosophila and mouse.". J. Biol. Chem. 273 (45): 29672–7. PMID 9792678.
Fanning AS, Jameson BJ, Jesaitis LA, Anderson JM (1998). "The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton.". J. Biol. Chem. 273 (45): 29745–53. PMID 9792688.
Itoh M, Morita K, Tsukita S (1999). "Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin.". J. Biol. Chem. 274 (9): 5981–6. PMID 10026224.
Yamamoto T, Harada N, Kawano Y, et al. (1999). "In vivo interaction of AF-6 with activated Ras and ZO-1.". Biochem. Biophys. Res. Commun. 259 (1): 103–7. doi:10.1006/bbrc.1999.0731. PMID 10334923.
Wittchen ES, Haskins J, Stevenson BR (2000). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3.". J. Biol. Chem. 274 (49): 35179–85. PMID 10575001.