Testosterone 17beta-dehydrogenase (NADP+)

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In enzymology, a testosterone 17beta-dehydrogenase (NADP+) (EC 1.1.1.64) is an enzyme that catalyzes the chemical reaction

testosterone + NADP⁺ $\rightleftharpoons$ androst-4-ene-3,17-dione + NADPH + H⁺

Thus, the two substrates of this enzyme are testosterone and NADP⁺, whereas its 3 products are androst-4-ene-3,17-dione, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 17beta-hydroxysteroid:NADP+ 17-oxidoreductase. Other names in common use include 17-ketoreductase, NADP+-dependent testosterone-17beta-oxidoreductase, and testosterone 17beta-dehydrogenase (NADP+). This enzyme participates in androgen and estrogen metabolism.

[edit] References

IUBMB entry for 1.1.1.64
BRENDA references for 1.1.1.64 (Recommended.)
PubMed references for 1.1.1.64
PubMed Central references for 1.1.1.64
Google Scholar references for 1.1.1.64
ENDAHL GL, KOCHAKIAN CD, HAMM D (1960). "Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine nucleotide-specific 17 beta-hydroxy-(testosterone) dehydrogenase of guinea pig liver". J. Biol. Chem. 235: 2792–6. PMID 13696735.
SWEAT ML, SAMUELS LT, LUMRY R (1950). "Preparation and characterization of the enzyme which converts testosterone to androstenedione". J. Biol. Chem. 185: 75–84. PMID 15436478.
Villee CA and Spencer JM (1960). "Some properties of the pyridine nucleotide-specific 17beta-hydroxy steroid dehydrogenase of guinea pig liver". J. Biol. Chem. 235: 3615–3619.