Tamsulosin
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Tamsulosin
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| Systematic (IUPAC) name | |
| (R)-5-(2-(2-(2-ethoxyphenoxy)ethylamino)propyl)- 2-methoxybenzenesulfonamide |
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| Identifiers | |
| CAS number | |
| ATC code | G04 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C20H28N2O5S |
| Mol. mass | 408.51 |
| SMILES | & |
| Pharmacokinetic data | |
| Bioavailability | 100% (oral) |
| Metabolism | hepatic |
| Half life | 9–13 hours |
| Excretion | 76% renal |
| Therapeutic considerations | |
| Pregnancy cat. |
B2 (Aust) |
| Legal status | |
| Routes | oral |
Tamsulosin (rINN) (pronounced /tæmˈsuːloʊsɪn/, /tæmsuˈloʊsɪn/) is an α1a-selective alpha blocker used in the symptomatic treatment of benign prostatic hyperplasia (BPH). Tamsulosin was developed by Yamanouchi Pharmaceuticals (now part of Astellas Pharma) and is marketed by various companies under licence, including Boehringer-Ingelheim and CSL. Tamsulosin hydrochloride extended-release tablets are marketed under the trade name Flomaxtra and Urimax. It was formerly marketed as modified-release capsules under the trade name Flomax.
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[edit] Clinical use
[edit] Adverse effects
Two ADRs (Adverse Drug Reactions) have been reported:
- Immunologic: It contains a sulfa moiety, thus causing typical reactions to sulfa drugs.
- Ophthalmologic: Patients taking tamsulosin are prone to a complication known as floppy iris syndrome during cataract surgery. Adverse outcomes of the surgery are greatly reduced by the surgeon's prior knowledge of the patient's history with this drug, and thus having the option of alternative techniques. [1]
Tamsulosin has also affected the sexual function in men. Tamsulosin can cause males to experience retrograde ejaculation.
[edit] Clinical comparison
Although prostate specific, it does not have the prostate apoptotic effects of other alpha-blockers such as doxazosin and terazosin.
[edit] Use in Combination Therapy
The results of the CombAT (Combination of Avodart and Tamsulosin) trial have recently demonstrated that treatment with the combination of dutasteride and tamsulosin provides superior symptom benefits compared with either monotherapy (http://www.ncbi.nlm.nih.gov/pubmed/18082216?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum).
[edit] External links
- Tamsulosin (systemic) – information from USP DI Advice for the Patient
- Flomax (drugs.com) – U.S. product information
- Flomax (Official Site) – Official Site
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