Talk:T cell

From Wikipedia, the free encyclopedia

	MCB Portal This article is within the scope of the Molecular and Cellular Biology WikiProject. To participate, visit the WikiProject for more information. The WikiProject's current monthly collaboration is focused on improving Restriction enzyme.
Start	This article has been rated as Start-Class on the assessment scale.
High	This article is on a subject of High-importance within molecular and cellular biology.
Article Grading: The article has been rated for quality and/or importance but has no comments yet. If appropriate, please review the article and then leave comments here to identify the strengths and weaknesses of the article and what work it will need.

	This article is within the scope of WikiProject Medicine. Please visit the project page for details or ask questions at the doctor's mess.
B	This page has been rated as B-Class on the quality assessment scale
Mid	This article has been rated as Mid-importance on the importance assessment scale

Contents 1 subsets 2 T cell maturation 3 Th40 cells 4 Tregs 5 Cytotoxic T Cells 6 γδ T cells 7 Hyphen or not? 8 Differential signaling 9 T cell Differentiation

[edit] subsets

Could we clarify if the listed subsets are distinct or overlapping. If overlapping then we could add CD4+ T cells and CD8+ T cells as they often refered to. It's not clear if there are 2 or 4 subtypes of memory T cells. Rod57 (talk) 13:14, 23 January 2008 (UTC)

[edit] T cell maturation

The T cell maturation section could be removed and used to update the T cell development section. Rod57 (talk) 13:14, 23 January 2008 (UTC)

Yes, I agree...someone should do this...It basically says the same thing at parts...Dan (talk) 23:16, 1 April 2008 (UTC)

[edit] Th40 cells

I've never heard of this nomenclature, and I can't find anything on Pubmed or google for "Th40" cells. It seems that the process described does occur, but I don't know of its relevance and it seems to be more of a mechanism of tolerance rather than an individual T cell subset. If someone can come up with some decent papers to show the opposite, I'm willing to be persuaded, otherwise it'll have to be deleted. Kantokano (talk) 14:54, 22 November 2007 (UTC)

I totally agree. This seems completely redundant. —Preceding unsigned comment added by 24.57.193.14 (talk) 00:18, 2 March 2008 (UTC)

[edit] Tregs

Does anyone know for sure if regulatory T cell is just a newer name for suppressor T cell, or if there is still some distinction between them? I would like to combine them under one article for regulatory t cell and relink it to this page. What do you think? Wiccan Quagga 16:40, 6 Feb 2005 (UTC)

More info about suppressor T cells at [1] Eleassar777 17:53, 6 Feb 2005 (UTC)

Well according to my 3rd year Immunology lecturer T_regs are definitely not the same as T_suppresors. If anything you might consider suppressor T cells a subset of regulatory T cells T_suppressors were the subject of much research in the 1980's but fell into some trouble and a coherent model was not established. A paper by Sakaguchi in 1995 revived interest in the idea when CD25+ CD4+ T cells were demonstrated to show suppressor function. These could be thought of as 'natural' suppressor cells since other T cells also display suppressor funtion, namely CD4+ CD25- Tr1 cells and Th3 cells. --schroding79 04:00, 22 September 2006 (UTC)

A slightly different historicism: To hear Ethan Shevach talk about the canonical CD4+CD25+FoxP3+ Treg, it's pretty much synonymous. To my understanding, the original "suppressor T" from the 70s literature simply didn't withstand the scrutiny of molecular characterization. When the Mosmann & Coffman Th1/Th2 model broke in the mid-80s, the "suppressor" model was thought to simply reflect the counterregulation of those populations. Jbarin 11:34, 21 November 2006 (UTC)

This is really something for the Treg article. . . Kantokano (talk) 14:54, 22 November 2007 (UTC)

[edit] Cytotoxic T Cells

someone might want to mention a few things about cytotoxic T cells. I think that most people tend to think of these cells when thinking of T cells. wikipedia already has an article for them. http://en.wikipedia.org/wiki/Cytotoxic_t_cell

The cytotoxic T cell section used to be there, but got hit by a vandal and went unnoticed...thanks for drawing this to our attention!! I put it back. Ciar 05:30, 22 May 2007 (UTC)

[edit] γδ T cells

The name looks weird but a quick Google seems to confirm it. Any info on γδ T cells would be great. Kevs 02:19, 29 August 2006 (UTC)

Updated on main page --schroding79 04:00, 22 September 2006 (UTC) Classical suppressor cells expressed the CD8 marker (same one as expressed by cytotoxic T lymphocytes). Richard Gershon (Yale University) was a pioneer researcher in this area. The field of suppressor (and "contrasuppressor") T cells became controversial and discredited when the restriction (MHC) elements and mechanism (suppressor factors) could not be elucidated.

[edit] Hyphen or not?

Throughout the article the term is spelled without a hyphen (T cell), except in the accompanying image for T cell activation, where it's inconsistently spelled "T-cell" and "T cell" - Can someone clarify the usage here? Is with or without hyphen preferred? Should there be a difference for hyphenated adejctives, as in "T-cell activation"?

Thanks, 216.165.126.18 14:30, 10 September 2007 (UTC)

It's not really a set phrase, so rules are as for normal hyphen usage. I'd just go with whatever makes sense at the time. Unless it's unclear that the "cell" refers to the "T", I'd stick with "T cell". But in some cases, as with "T-cell activation", where, to the non-specialist, there is the potential for confusion as to what is happening, I'd use a hyphen. Consult a copy of Fowler's! Kantokano 15:15, 10 September 2007 (UTC)

Thanks for clarifying! 216.165.126.18 16:17, 21 September 2007 (UTC)

[edit] Differential signaling

Differential signaling needs a disambiguation page to explain its relation to T cells...Dan (talk) 23:47, 27 March 2008 (UTC)

Sorry Dan, but I just thought it best to remove the link altogether since it (and the "poor" stub link above it) were not completely relevant to T cell anyway! ~ Ciar ~ _{(Talk to me!)} 00:15, 28 March 2008 (UTC)

I added it back a few days ago, and made a page for the links myself, but instead of putting it at the end, I incorporated it into the article, with links for more information. Dan (talk) 23:47, 3 April 2008 (UTC)

[edit] T cell Differentiation

Why is there not a section on differentiation? Dan (talk) 23:24, 1 April 2008 (UTC)

The page is pretty much still in its infancy, it seems, and needs a lot of TLC to add in a wealth of missing info. It could do with a regular editor to adopt it and build it up into a good article. If you up to the challenge, why not take it on Dan! :o) ~ Ciar ~ _{(Talk to me!)} 01:14, 2 April 2008 (UTC)