SX-3228
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SX-3228
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| Systematic (IUPAC) name | |
| 5,6,7,8-Tetrahydro-3-(5-methoxy-1,3,4-oxadiazol-2-yl)- 6-(phenylmethyl)-1,6-naphthyridin-2(1H)-one | |
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| ATC code | ? |
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| Chemical data | |
| Formula | C18H18N4O3 |
| Mol. mass | 338.361 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
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SX-3228 is a sedative and hypnotic drug used in scientific research. It has similar effects to sedative-hypnotic benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic.
SX-3228 is a subtype-selective GABAA agonist acting primarily at the α1 subtype. It thus has similar effects to other α1-selective drugs such as zolpidem and zaleplon in animal studies.[1][2] It only partly substitutes for ethanol, and is a strong sedative-hypnotic with only limited anxiolytic effects which appear only at doses that also produce significant sedation.[3][4]
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[edit] References
- ^ Sanger DJ. The effects of new hypnotic drugs in rats trained to discriminate ethanol. Behavioural Pharmacology. 1997 Aug;8(4):287-92.
- ^ Griebel G, Perrault G, Tan S, Schoemaker H, Sanger DJ. Comparison of the pharmacological properties of classical and novel BZ-omega receptor ligands. Behavioural Pharmacology. 1999 Sep;10(5):483-95.
- ^ Griebel G, Perrault G, Sanger DJ. Limited anxiolytic-like effects of non-benzodiazepine hypnotics in rodents. Journal of Psychopharmacology. 1998;12(4):356-65.
- ^ Alvariño F, Monti JM, Jantos H, Monti D. Effect of SX-3228, a selective ligand for the BZ1 receptor, on sleep and waking during the light-dark cycle in the rat. Brazilian Journal of Medical and Biological Research. 1999 Aug;32(8):1007-14.
