Mecloqualone
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Mecloqualone
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| Systematic (IUPAC) name | |
| 3-(2-chlorophenyl)-2-methyl-quinazolin-4-one | |
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C15H11ClN2O |
| Mol. mass | 270.714 |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
Mecloqualone (Nubarene, Casfen) is an analogue of methaqualone which was first made in 1960 [1] and marketed mainly in France and some other European countries. It has sedative, hypnotic and anxiolytic properties, and was used for the treatment of insomnia. [2] Mecloqualone is faster acting but shorter lasting than methaqualone and so was used only as a sleeping pill[3], in contrast to methaqualone which was used as a general purpose anxiolytic as well. Mecloqualone was never as widely used as methaqualone and is no longer prescribed because of concerns about its potential for abuse and overdose.
[edit] See also
[edit] References
- ^ Jackman GV, Petrow V, Stephenson O. Journal of Pharmacy and Pharmacology 1960; 12(9):528-9.
- ^ Mouren P, Giraud F, Pinsard N. "Clinical use of a new psycholeptic: Mecloqualone." (French) Marseille Medical 1963;100: 599-602. PMID 13936358
- ^ Dubnk B, Towne CA, Bush MT. "Detection, assay and rate of excretion of mecloqualone in animals and man." Toxicology and Applied Pharmacology 1969 Nov;15(3):632-41. PMID 5353825
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