Superoxide reductase

From Wikipedia, the free encyclopedia

In enzymology, a superoxide reductase (EC 1.15.1.2) is an enzyme that catalyzes the chemical reaction

reduced rubredoxin + superoxide + 2 H⁺ rubredoxin + H₂O₂

The 3 substrates of this enzyme are reduced rubredoxin, superoxide, and H⁺, whereas its two products are rubredoxin and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on superoxide as accepto acting on superoxide as acceptor (only sub-subclass identified t date). The systematic name of this enzyme class is rubredoxin:superoxide oxidoreductase. Other names in common use include neelaredoxin, and desulfoferrodoxin.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1VZG, 1VZH, 1VZI, 1Y07, 2AMU, 2HVB, 2JI1, 2JI2, and 2JI3.

[edit] References

• IUBMB entry for 1.15.1.2
• BRENDA references for 1.15.1.2 (Recommended.)
• PubMed references for 1.15.1.2
• PubMed Central references for 1.15.1.2
• Google Scholar references for 1.15.1.2
• Jenney FE Jr, Verhagen MF, Cui X, Adams MW (1999). "Anaerobic microbes: oxygen detoxification without superoxide dismutase". Science. 286: 306–9. doi:10.1126/science.286.5438.306. PMID 10514376. 
• Yeh AP, Hu Y, Jenney FE Jr, Adams MW, Rees DC (2000). "Structures of the superoxide reductase from Pyrococcus furiosus in the oxidized and reduced states". Biochemistry. 39: 2499–508. doi:10.1021/bi992428k. PMID 10704199. 
• Lombard M, Fontecave M, Touati D, Niviere V (2000). "Reaction of the desulfoferrodoxin from Desulfoarculus baarsii with superoxide anion. Evidence for a superoxide reductase activity". J. Biol. Chem. 275: 115–21. doi:10.1074/jbc.275.1.115. PMID 10617593. 
• Teixeira M (2000). "Oxygen detoxification in the strict anaerobic archaeon Archaeoglobus fulgidus: superoxide scavenging by neelaredoxin". Mol. Microbiol. 38: 322–34. doi:10.1046/j.1365-2958.2000.02121.x. PMID 11069658. 

[edit] External links

• IUBMB entry for 1.15.1.2

• KEGG entry for 1.15.1.2

• BRENDA entry for 1.15.1.2

• NiceZyme view of 1.15.1.2

• EC2PDB: PDB structures for 1.15.1.2

• PRIAM entry for 1.15.1.2

• PUMA2 entry for 1.15.1.2

• IntEnz: Integrated Enzyme entry for 1.15.1.2

• MetaCyc entry for 1.15.1.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050605: superoxide reductase

• AMIGO entry for GO code 0050605: superoxide reductase