Spectinomycin

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Spectinomycin
Systematic (IUPAC) name
(2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)- 4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino) decahydro-4H-pyrano[2,3-b][1,4]benzodioxin-4-one
Identifiers
CAS number	1695-77-8
ATC code	J01XX04
PubChem	15541
DrugBank	APRD01232
Chemical data
Formula	C14H24N2O7
Mol. mass	332.35 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	B(US)
Legal status	not available in US
Routes	?

Spectinomycin (marketed as the hydrochloride salt spectinomycin hydrochloride under the trade name Trobicin) is an aminocyclitol antibiotic produced by the bacterium Streptomyces spectabilis.

[edit] Mechanism

It binds to the 30S ribosomal subunit in invading bacteria and interrupts protein synthesis.

[edit] Uses

It is given by injection to treat gonorrhea, especially in patients who are allergic to penicillins.

[edit] Side effects

Side effects include itching, chills, stomach-ash, and red rash.

v • d • e Antibacterials for systemic use: aminoglycosides (J01G) -mycin (Streptomyces) Streptomycin • Neomycin (Framycetin, Paromomycin, Ribostamycin) • Kanamycin (Amikacin, Dibekacin, Tobramycin) • Hygromycin B • Spectinomycin -micin (Micromonospora) Gentamicin (Netilmicin, Sisomicin, Isepamicin) • Verdamicin

v • d • e Antibacterials for systemic use: others (J01X) Glycopeptide Vancomycin (Oritavancin, Telavancin) - Teicoplanin (Dalbavancin) Polymyxins Colistin - Polymyxin B Steroid antibacterials Fusidic acid Imidazole derivatives Metronidazole - Tinidazole - Ornidazole Nitrofuran derivatives Nitrofurantoin - Nifurtoinol Other -mycin (Fosfomycin, Spectinomycin, Daptomycin, Hitachimycin) Xibornol - Clofoctol - Methenamine - Iclaprim - Mandelic acid - Nitroxoline - Linezolid