Sorbose reductase

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In enzymology, a sorbose reductase (EC 1.1.1.289) is an enzyme that catalyzes the chemical reaction

D-glucitol + NADP⁺ $\rightleftharpoons$ L-sorbose + NADPH + H⁺

Thus, the two substrates of this enzyme are D-glucitol and NADP⁺, whereas its 3 products are L-sorbose, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-glucitol:NADP+ oxidoreductase. This enzyme is also called Sou1p.

[edit] References

IUBMB entry for 1.1.1.289
BRENDA references for 1.1.1.289 (Recommended.)
PubMed references for 1.1.1.289
PubMed Central references for 1.1.1.289
Google Scholar references for 1.1.1.289
Greenberg JR, Price NP, Oliver RP, Sherman F, Rustchenko E (2005). "Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization". Yeast. 22: 957–69. doi:10.1002/yea.1282. PMID 16134116.
Rustchenko E (2005). "Erratum report: Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization". Yeast 22: 1171.
Sugisawa T, Hoshino T and Fujiwara A (1991). "Purification and properties of NADPH-linked L-sorbose reductase from Gluconobacter melanogenus N44-1". Agric. Biol. Chem. 55: 2043–2049.
Shinjoh M, Tazoe M, Hoshino T (2002). "NADPH-dependent L-sorbose reductase is responsible for L-sorbose assimilation in Gluconobacter suboxydans IFO 3291". J. Bacteriol. 184: 861–3. PMID 11790761.