Sorbitol-6-phosphate 2-dehydrogenase

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In enzymology, a sorbitol-6-phosphate 2-dehydrogenase (EC 1.1.1.140) is an enzyme that catalyzes the chemical reaction

D-sorbitol 6-phosphate + NAD⁺ $\rightleftharpoons$ D-fructose 6-phosphate + NADH + H⁺

Thus, the two substrates of this enzyme are D-sorbitol 6-phosphate and NAD⁺, whereas its 3 products are D-fructose 6-phosphate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase. Other names in common use include ketosephosphate reductase, ketosephosphate reductase, D-sorbitol 6-phosphate dehydrogenase, D-sorbitol-6-phosphate dehydrogenase, sorbitol-6-P-dehydrogenase, and D-glucitol-6-phosphate dehydrogenase. This enzyme participates in fructose and mannose metabolism.

[edit] References

IUBMB entry for 1.1.1.140
BRENDA references for 1.1.1.140 (Recommended.)
PubMed references for 1.1.1.140
PubMed Central references for 1.1.1.140
Google Scholar references for 1.1.1.140
Du Toit PJ, Kotze JP (1970). "The isolation and characterization of sorbitol-6-phosphate dehydrogenase from Clostridium pasteurianum". Biochim. Biophys. Acta. 206: 333–42. PMID 4318899.
LISS M, HORWITZ SB, KAPLAN NO (1962). "D-Mannitol 1-phosphate dehydrogenase and D-sorbitol 6-phosphate dehydrogenase in Aerobacter aerogenes". J. Biol. Chem. 237: 1342–50. PMID 14465816.