SKP2

From Wikipedia, the free encyclopedia

S-phase kinase-associated protein 2 (p45)

PDB rendering based on 1fqv.

Available structures: 1fqv, 1fs1, 1ldk, 2ass, 2ast

Identifiers

Symbol(s)

SKP2; FBL1; FBXL1; FLB1; MGC1366

External IDs

OMIM: 601436 MGI: 1351663 HomoloGene: 55942

Gene ontology
Molecular Function:	• protein binding
Biological Process:	• regulation of progression through cell cycle • G1/S transition of mitotic cell cycle • ubiquitin cycle • cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005983 (mRNA)
NP_005974 (protein)

NM_013787 (mRNA)
NP_038815 (protein)

Location

Chr 5: 36.19 - 36.22 Mb

Chr 15: 9.04 - 9.07 Mb

Pubmed search

[1]

[2]

S-phase kinase-associated protein 2 (p45), also known as SKP2, is a human gene.^[1]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box^[2]. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-[[|F-box protein|F-box]]), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs^[3]. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19)^[4]^[5]. In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas^[6]. Alternative splicing of this gene generates 2 transcript variants encoding different isoforms.

[edit] References

^ Entrez Gene: SKP2 S-phase kinase-associated protein 2 (p45).
^ Bai et al. (1996). "SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.". Cell 86 (2): 263-74.
^ Kipreos ET, Pagano M. (2000). The F-box protein family. Genome Biol 1(5):REVIEWS3002. PMID 11178263
^ Carrano et al. "SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27.". Nat Cell Biol 1 (4): 193-9.
^ Tsvetkov et al. "p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27.". Curr Biol 9 (12).
^ Latres et al. "Role of the F-box protein Skp2 in lymphomagenesis.". Proc Natl Acad Sci U S A 98 (5): 2515-20.