SKP1A

From Wikipedia, the free encyclopedia

S-phase kinase-associated protein 1A (p19A)

PDB rendering based on 1fs1.

Available structures: 1fs1, 1fs2, 1ldk, 2ass, 2ast, 2e31, 2e32

Identifiers

Symbol(s)

SKP1A; EMC19; MGC34403; OCP-II; OCP2; SKP1; TCEB1L

External IDs

OMIM: 601434 MGI: 103575 HomoloGene: 38775

Gene ontology
Molecular Function:	• molecular_function • protein binding
Cellular Component:	• cellular_component
Biological Process:	• ubiquitin cycle • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006930 (mRNA)
NP_008861 (protein)

NM_011543 (mRNA)
NP_035673 (protein)

Location

Chr 5: 133.52 - 133.54 Mb

Chr 11: 52.08 - 52.09 Mb

Pubmed search

[1]

[2]

S-phase kinase-associated protein 1A (p19A), also known as SKP1A, is a human gene.^[1]

This gene encodes a protein that is a member of the SCF ubiquitin ligase protein complex. It binds to proteins containing an F-box motif, such as cyclin F, S-phase kinase-associated protein 2, and other regulatory proteins involved in ubiquitin dependent proteolysis^[2]. The encoded protein also collaborates with a network of proteins to control beta-catenin levels and affects the activity level of beta-catenin dependent TCF transcription factors. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.

[edit] References

^ Entrez Gene: SKP1A S-phase kinase-associated protein 1A (p19A).
^ Bai et al. (1996). "SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.". Cell 86 (2): 263–74. doi:10.1016/S0092-8674(00)80098-7.

[edit] Further reading

Zhang H, Kobayashi R, Galaktionov K, Beach D (1995). "p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase.". Cell 82 (6): 915–25. PMID 7553852.
Chen H, Thalmann I, Adams JC, et al. (1995). "cDNA cloning, tissue distribution, and chromosomal localization of Ocp2, a gene encoding a putative transcription-associated factor predominantly expressed in the auditory organs.". Genomics 27 (3): 389–98. doi:10.1006/geno.1995.1068. PMID 7558018.
Sowden J, Morrison K, Schofield J, et al. (1996). "A novel cDNA with homology to an RNA polymerase II elongation factor maps to human chromosome 5q31 (TCEB1L) and to mouse chromosome 11 (Tceb1l).". Genomics 29 (1): 145–51. doi:10.1006/geno.1995.1225. PMID 8530064.
Demetrick DJ, Zhang H, Beach DH (1996). "Chromosomal mapping of the genes for the human CDK2/cyclin A-associated proteins p19 (SKP1A and SKP1B) and p45 (SKP2).". Cytogenet. Cell Genet. 73 (1-2): 104–7. PMID 8646875.
Bai C, Sen P, Hofmann K, et al. (1996). "SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.". Cell 86 (2): 263–74. PMID 8706131.
Brown KA, Leek JP, Lench NJ, et al. (1996). "Human sequences homologous to the gene for the cochlear protein Ocp-II do not map to currently known non-syndromic hearing loss loci.". Ann. Hum. Genet. 60 (Pt 5): 385–9. PMID 8912791.
Liang Y, Chen H, Asher JH, et al. (1997). "Human inner ear OCP2 cDNA maps to 5q22-5q35.2 with related sequences on chromosomes 4p16.2-4p14, 5p13-5q22, 7pter-q22, 10 and 12p13-12qter.". Gene 184 (2): 163–7. PMID 9031623.
Lisztwan J, Marti A, Sutterlüty H, et al. (1998). "Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway.". EMBO J. 17 (2): 368–83. doi:10.1093/emboj/17.2.368. PMID 9430629.
Ng RW, Arooz T, Yam CH, et al. (1998). "Characterization of the cullin and F-box protein partner Skp1.". FEBS Lett. 438 (3): 183–9. PMID 9827542.
Yam CH, Ng RW, Siu WY, et al. (1999). "Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein Skp2.". Mol. Cell. Biol. 19 (1): 635–45. PMID 9858587.
Henzl MT, Thalmann I, Thalmann R (1999). "OCP2 exists as a dimer in the organ of Corti.". Hear. Res. 126 (1-2): 37–46. PMID 9872132.
Winston JT, Strack P, Beer-Romero P, et al. (1999). "The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro.". Genes Dev. 13 (3): 270–83. PMID 9990852.
Ilyin GP, Rialland M, Glaise D, Guguen-Guillouzo C (1999). "Identification of a novel Skp2-like mammalian protein containing F-box and leucine-rich repeats.". FEBS Lett. 459 (1): 75–9. PMID 10508920.
Cenciarelli C, Chiaur DS, Guardavaccaro D, et al. (1999). "Identification of a family of human F-box proteins.". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins.". Curr. Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
Suzuki H, Chiba T, Suzuki T, et al. (2000). "Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination.". J. Biol. Chem. 275 (4): 2877–84. PMID 10644755.
Read MA, Brownell JE, Gladysheva TB, et al. (2000). "Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha.". Mol. Cell. Biol. 20 (7): 2326–33. PMID 10713156.
Schulman BA, Carrano AC, Jeffrey PD, et al. (2000). "Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.". Nature 408 (6810): 381–6. doi:10.1038/35042620. PMID 11099048.
Lyapina S, Cope G, Shevchenko A, et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.". Science 292 (5520): 1382–5. doi:10.1126/science.1059780. PMID 11337588.
Fukuchi M, Imamura T, Chiba T, et al. (2001). "Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins.". Mol. Biol. Cell 12 (5): 1431–43. PMID 11359933.