Sirohydrochlorin ferrochelatase

From Wikipedia, the free encyclopedia

In enzymology, a sirohydrochlorin ferrochelatase (EC 4.99.1.4) is an enzyme that catalyzes the chemical reaction

siroheme + 2 H⁺ sirohydrochlorin + Fe₂+

Thus, the two substrates of this enzyme are siroheme and H⁺, whereas its two products are sirohydrochlorin and Fe2+.

This enzyme belongs to the family of lyases, specifically the "catch-all" class of lyases that do not fit into any other sub-class. The systematic name of this enzyme class is siroheme ferro-lyase (sirohydrochlorin-forming). Other names in common use include CysG, Met8P, SirB, and sirohydrochlorin ferro-lyase (incorrect). This enzyme participates in porphyrin and chlorophyll metabolism.

[edit] References

• IUBMB entry for 4.99.1.4
• BRENDA references for 4.99.1.4 (Recommended.)
• PubMed references for 4.99.1.4
• PubMed Central references for 4.99.1.4
• Google Scholar references for 4.99.1.4
• Warren MJ (2002). "The structure of Saccharomyces cerevisiae Met8p, a bifunctional dehydrogenase and ferrochelatase". EMBO. J. 21: 2068–75. doi:10.1093/emboj/21.9.2068. PMID 11980703. 
• Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (2002). "The biosynthesis of adenosylcobalamin (vitamin B12)". Nat. Prod. Rep. 19: 390–412. doi:10.1039/b108967f. PMID 12195810. 

[edit] External links

• IUBMB entry for 4.99.1.4

• KEGG entry for 4.99.1.4

• BRENDA entry for 4.99.1.4

• NiceZyme view of 4.99.1.4

• EC2PDB: PDB structures for 4.99.1.4

• PRIAM entry for 4.99.1.4

• PUMA2 entry for 4.99.1.4

• IntEnz: Integrated Enzyme entry for 4.99.1.4

• MetaCyc entry for 4.99.1.4

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0051266: sirohydrochlorin ferrochelatase

• AMIGO entry for GO code 0051266: sirohydrochlorin ferrochelatase