Talk:Simvastatin

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Contents 1 FDA 2 Penicillium 3 Question 4 Linkspam

[edit] FDA

I was disconcerted to see the FDA equated to Federal Drug Administration. It is not ! The acronym FDA stands for Food and Drug Administration. It controls the pruity of both foods and drugs.

Nwbeeson 17:43, 12 February 2007 (UTC)

[edit] Penicillium

Tabutterick 17:27, 7 October 2006 (UTC)—From website: By 1976, Akira Endo had isolated the first inhibitor (compactin) from yeast cultures in Sankyo, Japan. Correction needed:

Akira Endo had isolated the first inhibitor (compactin ML-236B) from the fungus, Penicillium citrinium in Sankyo, Japan. ref: Liao and Laufs, 2005. Pleiotropic Effects of Statins. Annu. Rev. Pharmacol.Toxicol:45:89-118

Pen. is not a yeast but a filamentous fungi. Since you listed the organism that sim. was isolated from you might want to include the name of this organism too.

Thank you for your time and I hope this is helpful. Tammy Butterick Third yr. Graduate Student UMN-Twin Cities Dept of Pharmacology [email address removed]

[edit] Question

My zocor was left in a rural mail box all day on a 90* day. checked temp. inside box. was over 150. Any damage? How tolerant is it to heat? Suggested max. was 89.

Sorry, you'd better check with a real pharmacist. JFW | T@lk 16:35, 2 January 2008 (UTC)

[edit] Linkspam

This article has been spammed several times now with the following link:

• Flash animation explaining in detail the mechanism of action of simvastatin. Requires flash 8 for visualisation

It is a fairly basic Flash animation that basically rehashes information already provided on statin with regards to the MOA of statins. I find it of no added informational value over the content already on the page. This Argentinian website has one other Flash animation (on benzodiazepines) and that is the entire content of the site. JFW | T@lk 16:35, 2 January 2008 (UTC)