Talk:Serotonin-norepinephrine reuptake inhibitor
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[edit] In
In my opinion there is some very questionable information on this page. The issue of which of these drugs is legitimately or meaningfully categorised as an serotonin and noradrenaline reuptake inhibitor (SNRI) is far from clear. Desipramine is the most specific noradrenaline reuptake inhibitor (NRI) of any of the tricyclic antidepressants (TCAs) and almost certainly has no significant serotonergic effects at all. The 'gold standard' serotonin and noradrenaline reuptake inhibitor (SNRI), of the TCAs, is clomipramine, and it has a stronger claim to serotonin and noradrenaline reuptake inhibitor (SNRI) status that venlafaxine see my review: GILLMAN, P.K. (2006). A review of serotonin toxicity data: implications for the mechanisms of antidepressant drug action. Biological Psychiatry, 59, 1046-51. Nefazodone has no significant evidence supporting serotonin and noradrenaline reuptake inhibitor (SNRI) effects, indeed is is not a reuptake inhibitor at all, perhaps not even an effective antidepressant. Those wishing for a comprehensive review may find it of some help to consult summaries about these topics available, with references, on my website. If anyone wishes to exerpt, quote or copy material to improve this entry they have my permission. See www.psychotropical.com
[edit] Other possible SNRIs?
I have read, although not from any reliable source, that the pain medication Tramadol (Ultram, Ultracet) is also a slight SNRI. If anyone knows more about this medicine it might be useful to add this drug to this page. I've heard of people taking Tramadol with other SSRIs and SNRIs and getting serotonin syndrome, because some doctors don't even know about Tramadol's anti-depressive effect. Icculusioso 00:42, 3 May 2007 (UTC)
I thought Straterra was also a SNRI. 70.69.148.3 (talk) 01:34, 23 January 2008 (UTC)
[edit] SERATONIN or SELECTIVE?
...er- although I have not graduated yet and am far from an expert I am well aware of selective norepinephrine re-uptake inhibitor (SNRI) antidepressants, but have never heard of the same abbreviation referring to "Serotonin-norepinephrine re-uptake inhibitor" type antidepressant drugs. I believe this may be a misunderstanding on the part of the author and hope a kind professional/academic might find the time to either authenticate, edit, merge or delete this article accordingly.
Thanks all, and all hail the free encyclopedia!
Toby84.43.122.165 (talk) 23:26, 13 January 2008 (UTC)
OK sorry - think I'm going nuts myself! Have been up far too long writing an unrelated paper & was trying to procrastinate.... Perhaps they are seratonin-norepinephrine RIs...
So long, T 84.43.122.165 (talk) 23:33, 13 January 2008 (UTC)
SNRI is serotonin norepinephrine reuptake inhibitors, and the "specific" is assumed, probably because SSNRI seemed too long. "Specific norepinephrine reuptake inhibitors" is abbreviated "NRI" with the specific assumed again. Psydzl (talk) 18:18, 11 February 2008 (UTC)
Ok I was asked to propose this here on the talk page. I have extensive experience w/ these agents and have spent a considerable amount of my adult years studying and marketing these types of medicines. The correct term to describe a dual acting agent (serontonin/norepinephrine) is referred to as an SSNRI which stands for Selective Serotonin Norepinephrine Reuptake Inhibitor. Now not all SNRI's are considered SSNRI's... which may be part of the confusion. Really the first of the class of SSNRI's was duloxetine, a.k.a. Cymbalta. Even Effexor XR can be considered an SSNRI but those are really the only two that act equally on both receptor sites.
So I propose for the sake of accuracy that we correctly refer to this new class as SSNRI rather than lumping them all into the SNRI classification.
In addition if you do a google search on just the term 'SSNRI' the first result is a wikipedia page with the URL en.wikipedia.org/wiki/SSNRI and a title that says, "SSNRI." So it is in fact misleading to then bring the visitor to a page that uses the term SNRI because that is not what they were looking for.
Thoughts? —Preceding unsigned comment added by Mdphd (talk • contribs) 22:04, 21 May 2008 (UTC)
Mdphd (talk) 22:06, 21 May 2008 (UTC)
- Per MEDMOS, I'm not certain if that change would be appropriate. A PubMed search for "SSNRI" yields only 4 results, and only 2 of these are in English. (This is compared to 2546 for "SSRI" and 184 for "SNRI".) --Arcadian (talk) 02:46, 22 May 2008 (UTC)
[edit] Nefazadone liver failure
The text currently says that a blood test every six months is sufficient for the prevention of liver failure with nefazadone, but I don't think that's correct. I think the liver failure tends to occur very rapidly. There is extensive damage in the abscence of a prodrome of gradually increasing serum liver enzymes. Psydzl (talk) 18:15, 11 February 2008 (UTC)
