Sepiapterin reductase

From Wikipedia, the free encyclopedia

In enzymology, a sepiapterin reductase (EC 1.1.1.153) is an enzyme that catalyzes the chemical reaction

7,8-dihydrobiopterin + NADP⁺ sepiapterin + NADPH + H⁺

Thus, the two substrates of this enzyme are 7,8-dihydrobiopterin and NADP⁺, whereas its 3 products are sepiapterin, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 7,8-dihydrobiopterin:NADP+ oxidoreductase. This enzyme participates in folate biosynthesis.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1NAS, 1OAA, 1SEP, 1Z6Z, and 2BD0.

[edit] References

• IUBMB entry for 1.1.1.153
• BRENDA references for 1.1.1.153 (Recommended.)
• PubMed references for 1.1.1.153
• PubMed Central references for 1.1.1.153
• Google Scholar references for 1.1.1.153
• Katoh S (1971). "Sepiapterin reductase from horse liver: purification and properties of the enzyme". Arch. Biochem. Biophys. 146: 202–214. doi:10.1016/S0003-9861(71)80057-7. 
• Matsubara M, Katoh S, Akino M, Kaufman S (1966). "Sepiapterin reductase". Biochim. Biophys. Acta. 122: 202–12. PMID 5969298. 

[edit] External links

The CAS registry number for this enzyme class is 9059-48-7.

• IUBMB entry for 1.1.1.153

• KEGG entry for 1.1.1.153

• BRENDA entry for 1.1.1.153

• NiceZyme view of 1.1.1.153

• EC2PDB: PDB structures for 1.1.1.153

• PRIAM entry for 1.1.1.153

• PUMA2 entry for 1.1.1.153

• IntEnz: Integrated Enzyme entry for 1.1.1.153

• MetaCyc entry for 1.1.1.153

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004757: sepiapterin reductase

• AMIGO entry for GO code 0004757: sepiapterin reductase