Secologanin synthase

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In enzymology, a secologanin synthase (EC 1.3.3.9) is an enzyme that catalyzes the chemical reaction

loganin + NADPH + H⁺ + O₂ $\rightleftharpoons$ secologanin + NADP⁺ + 2 H₂O

The 4 substrates of this enzyme are loganin, NADPH, H⁺, and O₂, whereas its 3 products are secologanin, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is loganin:oxygen oxidoreductase (ring-cleaving). This enzyme participates in indole and ipecac alkaloid biosynthesis.

[edit] References

IUBMB entry for 1.3.3.9
BRENDA references for 1.3.3.9 (Recommended.)
PubMed references for 1.3.3.9
PubMed Central references for 1.3.3.9
Google Scholar references for 1.3.3.9
Yamamoto H, Katano N, Ooi A, Inoue K (2000). "Secologanin synthase which catalyzes the oxidative cleavage of loganin into secologanin is a cytochrome P450". Phytochemistry. 53: 7–12. doi:10.1016/S0031-9422(99)00471-9. PMID 10656401.
Strack D, Matern U, Schroder J (2000). "Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase". Plant. J. 24: 797–804. doi:10.1046/j.1365-313x.2000.00922.x. PMID 11135113.
Yamamoto H, Katano N, Ooi Y and Inoue K (1999). "Transformation of loganin and 7-deoxyloganin into secologanin by Lonicera japonica cell suspension cultures". Phytochemistry 50: 417–422. doi:10.1016/S0031-9422(98)00613-X.