Talk:Salmeterol

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[edit] I

I am an African American and I wanted to know why does asthma affect African Americans more so than their counterparts and also what part does salmeterol play? 130.156.7.236 16:35, 7 March 2007 (UTC)

In my observations Asthma is very non-discriminatory, thus affects all races. RonEJ 19:23, 17 March 2007 (UTC)

The National Center for Health Statistics disagree with user RonEJ and report that in 2004 the prevalence of [asthma] in black children was 12.5% compared to 7.1% in Hispanic children and 7.5% in white children. There are multiple genes which may affect which persons are susceptible to developing asthma, however environmental factors (allergen/tobacco smoke exposure etc.) play a role as well. Twin and family studies prove that asthma is very discriminatory... in Norway, for example, a study showed that the regular incidence of asthma was 6%, however if your identical twin suffered from asthma, you had a 17% chance of developing this disease. Regarding the first user's question regarding salmeterol. The Salmeterol Multi-Center Asthma Research Trial was a large trial of more than 26,000 patients which was terminated early due to an unexpected number of deaths in patients receiving the experimental therapy salmeterol, (which is a long acting beta agonist bronchodilator) versus albuterol (a short acting beta agonist bronchodilator). Post hoc analysis did reveal an increased risk of death in African American patients with asthma who received salmeterol. This study was flawed, in that none of the patients received inhaled steroids, which is standard therapy for asthma. A follow up study in the United Kingdom, the Salmeterol Nationwide Surveillance Study, did include patients receiving inhaled steroids. This study showed a trend toward adverse effects in the salmeterol group, however the result was not statistically significant, therefore a larger trial would be needed to resolve the issue. Also, this study did not perform a sub-set analysis to determine if a certain race was more susceptible to this effect. The current recommendation is to not use salmeterol without co-current corticosteroid therapy in asthma patients. It is important to remember that this only applies to asthma patients, and patients with COPD (chronic obstructive pulmonary disease; emphysema; chronic bronchitis) safely benefit from the use of salmeterol in conjunction with inhaled corticosteroids (hence the combination drug Advair). Lugogo NJ, Kraft M. "Epidemiology of Asthma." Clinics in Chest Medicine. 2006. 27(1):1-15. Northwest girl 08:02, 6 November 2007 (UTC)

[edit] "Disk-styled" Inhaler

What does this refer to exactly? Is it what's sometimes known as an accuhaler? I have one of those for flixotide, I think it might be worth noting if they are the same thing. cyclosarin (talk) 03:16, 24 March 2008 (UTC)