Ribose 1-dehydrogenase (NADP+)

From Wikipedia, the free encyclopedia

In enzymology, a ribose 1-dehydrogenase (NADP+) (EC 1.1.1.115) is an enzyme that catalyzes the chemical reaction

D-ribose + NADP⁺ + H₂O D-ribonate + NADPH + H⁺

The three substrates of this enzyme are D-ribose, NADP⁺, and H₂O, whereas its 3 products are D-ribonate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-ribose:NADP+ 1-oxidoreductase. Other names in common use include D-ribose dehydrogenase (NADP+), NADP+-pentose-dehydrogenase, and ribose 1-dehydrogenase (NADP+).

[edit] References

• IUBMB entry for 1.1.1.115
• BRENDA references for 1.1.1.115 (Recommended.)
• PubMed references for 1.1.1.115
• PubMed Central references for 1.1.1.115
• Google Scholar references for 1.1.1.115
• Scher BM, Horecker BL (1966). "Pentose metabolism in Candida. 3. The triphosphopyridine nucleotide-specific polyol dehydrogenase of Candida utilis". Arch. Biochem. Biophys. 116: 117–28. doi:10.1016/0003-9861(66)90020-8. PMID 4381350. 
• Schiwara HW, Domschke W, Domagk GF (1968). "[Sugar dehydrogenases in mammalian liver. I. Differentiation of various sugar dehydrogenases from pig liver by disc electrophoresis and ion exchange chromatography]". Hoppe. Seylers. Z. Physiol. Chem. 349: 1575–81. PMID 4393642. 

[edit] External links

The CAS registry number for this enzyme class is 37250-46-7.

• IUBMB entry for 1.1.1.115

• KEGG entry for 1.1.1.115

• BRENDA entry for 1.1.1.115

• NiceZyme view of 1.1.1.115

• EC2PDB: PDB structures for 1.1.1.115

• PRIAM entry for 1.1.1.115

• PUMA2 entry for 1.1.1.115

• IntEnz: Integrated Enzyme entry for 1.1.1.115

• MetaCyc entry for 1.1.1.115

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050259: ribose 1-dehydrogenase (NADP+)

• AMIGO entry for GO code 0050259: ribose 1-dehydrogenase (NADP+)