NADPH:quinone reductase

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In enzymology, a NADPH:quinone reductase (EC 1.6.5.5) is an enzyme that catalyzes the chemical reaction

NADPH + H⁺ + quinone NADP⁺ + semiquinone

The 3 substrates of this enzyme are NADPH, H⁺, and quinone, whereas its two products are NADP⁺ and semiquinone.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with a quinone or similar compound as acceptor. The systematic name of this enzyme class is NADPH:quinone oxidoreductase. This enzyme is also called NADPH2:quinone reductase.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1IYZ, 1IZ0, and 1YB5.

[edit] References

• IUBMB entry for 1.6.5.5
• BRENDA references for 1.6.5.5 (Recommended.)
• PubMed references for 1.6.5.5
• PubMed Central references for 1.6.5.5
• Google Scholar references for 1.6.5.5
• Rao PV, Krishna CM, Zigler JS Jr (1992). "Identification and characterization of the enzymatic activity of zeta-crystallin from guinea pig lens. A novel NADPH:quinone oxidoreductase". J. Biol. Chem. 267: 96–102. PMID 1370456. 

[edit] External links

The CAS registry number for this enzyme class is 9032-20-6.

• IUBMB entry for 1.6.5.5

• KEGG entry for 1.6.5.5

• BRENDA entry for 1.6.5.5

• NiceZyme view of 1.6.5.5

• EC2PDB: PDB structures for 1.6.5.5

• PRIAM entry for 1.6.5.5

• PUMA2 entry for 1.6.5.5

• IntEnz: Integrated Enzyme entry for 1.6.5.5

• MetaCyc entry for 1.6.5.5

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0003960: NADPH:quinone reductase

• AMIGO entry for GO code 0003960: NADPH:quinone reductase