Talk:Pseudoxanthoma elasticum

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[edit] I

I hold the copyright to this document. I am the author of the document. I am also the founder and chief officer of PXE International.

By editing text in wikipedia you agree to license all contributions under the GFDL as explained on the edit screen. See Wikipedia:Ownership of articles and WP:GFDL If you have any questions feel free to ask them on my talk page. - cohesion★talk 05:42, 26 February 2006 (UTC)

This means anyone can edit your article at any time. You should probably keep an eye on it to defend from vandalism. Hope the edit I just made is acceptable. --Pansophia 07:49, 27 February 2006 (UTC)

Sfterry - if you return, please let me know the reference for minimizing cardio and gastrio symptoms as "rare". Has some recent study shifted medical consensus on this?

yes, a huge study that is in press. I will reference it as soon as it is published. I am not sure why someone is adding incorrect and inaccurate information - there is no hang-dog condition associated with PXE - I have physically examined 600 of the known 3000 individuals with this condition - none have the condition you describe. In addition, it is well known that angioid streaks do not cause vision loss. Again, after examining 600 individuals and the angiograms of another 300, we are certain of this fact.

Hi, shouldn't it read "discovered" rather than "invented the gene" bearing in mind you can't invent something that already exists? Also do you think it would be worthwhile mentioning it's association with mitral valve prolapse - thats a sincere question; I'm not an expert. Cheers 165.118.1.50 06:50, 20 June 2007 (UTC) Luke

I would prefer discovered, but the technical term in both science and law is invented. In our study about to be published of 600 individuals with PXE, the MVP rate was lower than the general public. The 'association' was determined by a few case studies about 30 years ago and has no evidence base. Sfterry

[edit] Need for improvement

I have identified PMID 15970621 and PMID 15894595 as useful recent clinical reviews of PXE. The article could be greatly expanded with these recent papers. JFW | T@lk 22:17, 18 July 2007 (UTC)

[edit] Uh oh

ABCC6 Heterozygotes can still get ocular and cardiac complications: http://archderm.ama-assn.org/cgi/content/full/144/3/301 JFW | T@lk 20:23, 26 March 2008 (UTC)