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Log page index: User:ProteinBoxBot/PBB_Log_Index
[edit] Protein Status Quick Log - Date: 01:22, 8 November 2007 (UTC)
[edit] Proteins without matches (16)
[edit] Proteins with a High Potential Match (9)
[edit] Created (6)
[edit] Manual Inspection (Page not found) (19)
[edit] Protein Status Grid - Date: 01:22, 8 November 2007 (UTC)
| HUGO Symbol |
Action Summary |
Target page(s) |
WP Symbol Search |
| UNG |
Manual Inspection (Page not found) |
Other Pages: Uracil-DNA glycosylase (No Data); UNG (No Data); DGU (Redirect -> Dongguk University); Dgu (No Data); DKFZp781L1143 (No Data); Dkfzp781l1143 (No Data); HIGM4 (No Data); Higm4 (No Data); UDG (DisAmbig); Udg (No Data); UNG1 (No Data); Ung1 (No Data); UNG15 (No Data); Ung15 (No Data); Dongguk University (Unknown Data); |
[1] |
| KRT1 |
Manual Inspection (Page not found) |
Other Pages: Keratin 1 (Protein Template); KRT1 (No Data); CK1 (No Data); Ck1 (Redirect -> Casein kinase 1); EHK1 (No Data); Ehk1 (No Data); K1 (DisAmbig); KRT1A (No Data); Krt1a (No Data); Casein kinase 1 (Protein Template); |
[2] |
| SLPI |
Manual Inspection (Page not found) |
Other Pages: Secretory leukocyte peptidase inhibitor (No Data); SLPI (No Data); ALK1 (No Data); Alk1 (No Data); ALP (Redirect -> Australian Labor Party); Alp (Unknown Data); MPI (DisAmbig); Mpi (Unknown Data); BLPI (Redirect -> Bolshevik-Leninist Party of India, Ceylon and Burma); Blpi (No Data); HUSI (No Data); Husi (Redirect -> Huşi); HUSI-I (No Data); Husi-i (No Data); WAP4 (No Data); Wap4 (No Data); WFDC4 (No Data); Wfdc4 (No Data); Australian Labor Party (Unknown Data); Bolshevik-Leninist Party of India, Ceylon and Burma (Unknown Data); Huşi (Unknown Data); |
[3] |
| CD47 |
Manual Inspection (Page not found) |
Other Pages: CD47 molecule (No Data); CD47 (No Data); IAP (DisAmbig); Iap (No Data); MER6 (No Data); Mer6 (No Data); OA3 (No Data); Oa3 (No Data); |
[4] |
| SREBF2 |
Created |
Other Pages: Sterol regulatory element binding transcription factor 2 (No Data); SREBF2 (No Data); SREBP2 (No Data); Srebp2 (No Data); |
[5] |
| STAT2 |
Manual Inspection (Page not found) |
Other Pages: Signal transducer and activator of transcription 2 (No Data); STAT2 (Protein Template); ISGF-3 (No Data); Isgf-3 (No Data); MGC59816 (No Data); Mgc59816 (No Data); P113 (No Data); STAT113 (No Data); Stat113 (No Data); |
[6] |
| CD8A |
Manual Inspection (Page not found) |
Other Pages: CD8a molecule (No Data); CD8A (No Data); P32 (Redirect -> Kel-Tec P-32); CD8 (Protein Template); Cd8 (No Data); Leu2 (No Data); MAL (DisAmbig); Mal (DisAmbig); Kel-Tec P-32 (Unknown Data); |
[7] |
| ENO1 |
Manual Inspection (Page not found) |
Other Pages: Enolase 1, (No Data); ENO1 (Redirect -> Alpha-enolase); ENO1L1 (No Data); Eno1l1 (No Data); MBP-1 (No Data); Mbp-1 (No Data); MPB1 (No Data); Mpb1 (No Data); NNE (DisAmbig); Nne (No Data); PPH (DisAmbig); Pph (No Data); Alpha-enolase (Protein Template); |
[8] |
| VASP |
Manual Inspection (Page not found) |
Other Pages: Vasodilator-stimulated phosphoprotein (No Data); VASP (Unknown Data); |
[9] |
| CAPN10 |
Created |
Other Pages: Calpain 10 (No Data); CAPN10 (No Data); |
[10] |
| PIAS1 |
Manual Inspection (Page not found) |
Other Pages: Protein inhibitor of activated STAT (No Data); PIAS1 (No Data); GBP (Redirect -> Pound sterling); Gbp (No Data); DDXBP1 (No Data); Ddxbp1 (No Data); MGC141878 (No Data); Mgc141878 (No Data); MGC141879 (No Data); Mgc141879 (No Data); ZMIZ3 (No Data); Zmiz3 (No Data); Pound sterling (Unknown Data); |
[11] |
| ADD1 |
Manual Inspection (Page not found) |
Other Pages: Adducin 1 (No Data); ADD1 (No Data); ADDA (No Data); Adda (DisAmbig); MGC3339 (No Data); Mgc3339 (No Data); MGC44427 (No Data); Mgc44427 (No Data); |
[12] |
| IQGAP1 |
Manual Inspection (Page not found) |
Other Pages: IQ motif containing GTPase activating protein 1 (No Data); IQGAP1 (No Data); HUMORFA01 (No Data); Humorfa01 (No Data); KIAA0051 (No Data); Kiaa0051 (No Data); SAR1 (No Data); Sar1 (Unknown Data); P195 (No Data); |
[13] |
| ID2 |
Created |
Other Pages: Inhibitor of DNA binding 2 (No Data); ID2 (No Data); GIG8 (No Data); Gig8 (No Data); ID2A (No Data); Id2a (No Data); ID2H (No Data); Id2h (No Data); MGC26389 (No Data); Mgc26389 (No Data); |
[14] |
| CHRM2 |
Manual Inspection (Page not found) |
Other Pages: Cholinergic receptor (Redirect -> Acetylcholine receptor); CHRM2 (No Data); FLJ43243 (No Data); Flj43243 (No Data); HM2 (No Data); Hm2 (No Data); MGC120006 (No Data); Mgc120006 (No Data); MGC120007 (No Data); Mgc120007 (No Data); Acetylcholine receptor (Unknown Data); |
[15] |
| ADAR |
Manual Inspection (Page not found) |
Other Pages: Adenosine deaminase (Protein Template); ADAR (No Data); ADAR1 (No Data); Adar1 (No Data); DRADA (No Data); Drada (No Data); DSH (DisAmbig); Dsh (No Data); DSRAD (No Data); Dsrad (No Data); G1P1 (No Data); G1p1 (No Data); IFI-4 (No Data); Ifi-4 (No Data); IFI4 (No Data); Ifi4 (No Data); K88dsRBP (No Data); K88dsrbp (No Data); P136 (No Data); |
[16] |
| C5 |
Manual Inspection (Page not found) |
Other Pages: Complement component 5 (Protein Template); C5 (DisAmbig); CPAMD4 (No Data); Cpamd4 (No Data); MGC142298 (No Data); Mgc142298 (No Data); |
[17] |
| CYP27B1 |
Manual Inspection (Page not found) |
Other Pages: Cytochrome P450 (Unknown Data); CYP27B1 (Redirect -> 25-Hydroxyvitamin D3 1-alpha-Hydroxylase); CYP1 (No Data); Cyp1 (No Data); CP2B (No Data); Cp2b (No Data); CYP1alpha (No Data); Cyp1alpha (No Data); CYP27B (No Data); Cyp27b (No Data); P450c1 (No Data); PDDR (No Data); Pddr (No Data); VDD1 (No Data); Vdd1 (No Data); VDDR (No Data); Vddr (No Data); VDDRI (No Data); Vddri (No Data); VDR (DisAmbig); Vdr (No Data); 25-Hydroxyvitamin D3 1-alpha-Hydroxylase (Protein Template); |
[18] |
| DNMT3B |
Manual Inspection (Page not found) |
Other Pages: DNA -methyltransferase 3 beta (No Data); DNMT3B (Protein Template); ICF (DisAmbig); Icf (Redirect -> iCF); M.HsaIIIB (No Data); M.hsaiiib (No Data); |
[19] |
| GPX1 |
Created |
Other Pages: Glutathione peroxidase 1 (No Data); GPX1 (No Data); GSHPX1 (No Data); Gshpx1 (No Data); MGC14399 (No Data); Mgc14399 (No Data); MGC88245 (No Data); Mgc88245 (No Data); |
[20] |
| CTCF |
Manual Inspection (Page not found) |
Other Pages: CCCTC-binding factor (No Data); CTCF (Protein Template); |
[21] |
| PPARBP |
Manual Inspection (Page not found) |
Other Pages: PPAR binding protein (No Data); PPARBP (No Data); PBP (DisAmbig); Pbp (No Data); CRSP1 (No Data); Crsp1 (No Data); CRSP200 (No Data); Crsp200 (No Data); DRIP205 (No Data); Drip205 (No Data); DRIP230 (No Data); Drip230 (No Data); MED1 (No Data); Med1 (No Data); MGC71488 (No Data); Mgc71488 (No Data); PPARGBP (No Data); Ppargbp (No Data); RB18A (No Data); Rb18a (No Data); TRAP220 (No Data); Trap220 (No Data); TRIP2 (No Data); Trip2 (No Data); |
[22] |
| GAB1 |
Created |
Other Pages: GRB2-associated binding protein 1 (No Data); GAB1 (No Data); |
[23] |
| GATA4 |
Created |
Other Pages: GATA binding protein 4 (No Data); GATA4 (No Data); MGC126629 (No Data); Mgc126629 (No Data); |
[24] |
| GATA3 |
Manual Inspection (Page not found) |
Other Pages: GATA binding protein 3 (No Data); GATA3 (No Data); HDR (DisAmbig); Hdr (Redirect -> HDR); MGC2346 (No Data); Mgc2346 (No Data); MGC5199 (No Data); Mgc5199 (No Data); MGC5445 (No Data); Mgc5445 (No Data); |
[25] |
[edit] Vebose Log - Date: 01:22, 8 November 2007 (UTC)
- INFO: Beginning work on ADAR... {November 7, 2007 4:49:02 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 4:49:37 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:50:14 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ADAR_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1qbj.
| PDB = {{PDB2|1qbj}}, {{PDB2|1qgp}}, {{PDB2|1xmk}}, {{PDB2|2acj}}, {{PDB2|2gxb}}
| Name = Adenosine deaminase, RNA-specific
| HGNCid = 225
| Symbol = ADAR
| AltSymbols =; ADAR1; DRADA; DSH; DSRAD; G1P1; IFI-4; IFI4; K88dsRBP; p136
| OMIM = 601059
| ECnumber =
| Homologene = 9281
| MGIid = 1889575
| GeneAtlas_image1 = PBB_GE_ADAR_201786_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003725 |text = double-stranded RNA binding}} {{GNF_GO|id=GO:0003726 |text = double-stranded RNA adenosine deaminase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0016553 |text = base conversion or substitution editing}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 103
| Hs_Ensembl = ENSG00000160710
| Hs_RefseqProtein = NP_001020278
| Hs_RefseqmRNA = NM_001025107
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 152821161
| Hs_GenLoc_end = 152867098
| Hs_Uniprot = P55265
| Mm_EntrezGene = 56417
| Mm_Ensembl = ENSMUSG00000027951
| Mm_RefseqmRNA = NM_001038587
| Mm_RefseqProtein = NP_001033676
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 89800987
| Mm_GenLoc_end = 89839372
| Mm_Uniprot = Q5J3Q8
}}
}}
'''Adenosine deaminase, RNA-specific''', also known as '''ADAR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref>{{cite web | title = Entrez Gene: ADAR adenosine deaminase, RNA-specific| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=103| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ADD1... {November 7, 2007 4:50:14 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:51:28 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Adducin 1 (alpha)
| HGNCid = 243
| Symbol = ADD1
| AltSymbols =; ADDA; MGC3339; MGC44427
| OMIM = 102680
| ECnumber =
| Homologene = 22758
| MGIid = 87918
| GeneAtlas_image1 = PBB_GE_ADD1_208030_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ADD1_214726_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_ADD1_214736_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 118
| Hs_Ensembl = ENSG00000087274
| Hs_RefseqProtein = NP_001110
| Hs_RefseqmRNA = NM_001119
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 2815382
| Hs_GenLoc_end = 2901587
| Hs_Uniprot =
| Mm_EntrezGene = 11518
| Mm_Ensembl = ENSMUSG00000029106
| Mm_RefseqmRNA = NM_001024458
| Mm_RefseqProtein = NP_001019629
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 34890720
| Mm_GenLoc_end = 34949162
| Mm_Uniprot = Q8BJT2
}}
}}
'''Adducin 1 (alpha)''', also known as '''ADD1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.<ref>{{cite web | title = Entrez Gene: ADD1 adducin 1 (alpha)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=118| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Mangeat PH |title=Interaction of biological membranes with the cytoskeletal framework of living cells. |journal=Biol. Cell |volume=64 |issue= 3 |pages= 261-81 |year= 1989 |pmid= 2976282 |doi= }}
*{{cite journal | author=Matsuoka Y, Li X, Bennett V |title=Adducin: structure, function and regulation. |journal=Cell. Mol. Life Sci. |volume=57 |issue= 6 |pages= 884-95 |year= 2000 |pmid= 10950304 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on C5... {November 7, 2007 4:51:28 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 4:51:58 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:52:11 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_C5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cfa.
| PDB = {{PDB2|1cfa}}, {{PDB2|1kjs}}, {{PDB2|1xwe}}
| Name = Complement component 5
| HGNCid = 1331
| Symbol = C5
| AltSymbols =; CPAMD4; MGC142298
| OMIM = 120900
| ECnumber =
| Homologene = 20412
| MGIid = 96031
| GeneAtlas_image1 = PBB_GE_C5_205500_at_tn.png
| Function = {{GNF_GO|id=GO:0004866 |text = endopeptidase inhibitor activity}} {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0008009 |text = chemokine activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005579 |text = membrane attack complex}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0000187 |text = activation of MAPK activity}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006956 |text = complement activation}} {{GNF_GO|id=GO:0006957 |text = complement activation, alternative pathway}} {{GNF_GO|id=GO:0006958 |text = complement activation, classical pathway}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0019835 |text = cytolysis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 727
| Hs_Ensembl = ENSG00000106804
| Hs_RefseqProtein = NP_001726
| Hs_RefseqmRNA = NM_001735
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 122754437
| Hs_GenLoc_end = 122852375
| Hs_Uniprot = P01031
| Mm_EntrezGene = 15139
| Mm_Ensembl = ENSMUSG00000026874
| Mm_RefseqmRNA = NM_010406
| Mm_RefseqProtein = NP_034536
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 34805340
| Mm_GenLoc_end = 34883447
| Mm_Uniprot = Q8BNV3
}}
}}
'''Complement component 5''', also known as '''C5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CAPN10... {November 7, 2007 5:13:31 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 5:14:20 PM PST}
- CREATED: Created new protein page: CAPN10 {November 7, 2007 5:14:28 PM PST}
- INFO: Beginning work on CD47... {November 7, 2007 4:52:59 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:54:20 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CD47 molecule
| HGNCid = 1682
| Symbol = CD47
| AltSymbols =; IAP; MER6; OA3
| OMIM = 601028
| ECnumber =
| Homologene = 1346
| MGIid = 96617
| GeneAtlas_image1 = PBB_GE_CD47_213857_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CD47_211075_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_CD47_213055_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007160 |text = cell-matrix adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 961
| Hs_Ensembl = ENSG00000196776
| Hs_RefseqProtein = NP_001020250
| Hs_RefseqmRNA = NM_001025079
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 109244631
| Hs_GenLoc_end = 109292625
| Hs_Uniprot = Q08722
| Mm_EntrezGene = 16423
| Mm_Ensembl = ENSMUSG00000055447
| Mm_RefseqmRNA = NM_010581
| Mm_RefseqProtein = NP_034711
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 49775244
| Mm_GenLoc_end = 49834636
| Mm_Uniprot = Q3U967
}}
}}
'''CD47 molecule''', also known as '''CD47''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: CD47 CD47 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=961| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Brown EJ, Frazier WA |title=Integrin-associated protein (CD47) and its ligands. |journal=Trends Cell Biol. |volume=11 |issue= 3 |pages= 130-5 |year= 2001 |pmid= 11306274 |doi= }}
*{{cite journal | author=Oldenborg PA |title=Role of CD47 in erythroid cells and in autoimmunity. |journal=Leuk. Lymphoma |volume=45 |issue= 7 |pages= 1319-27 |year= 2004 |pmid= 15359629 |doi= 10.1080/1042819042000201989 }}
*{{cite journal | author=Kaczorowski DJ, Billiar TR |title=Targeting CD47: NO limit on therapeutic potential. |journal=Circ. Res. |volume=100 |issue= 5 |pages= 602-3 |year= 2007 |pmid= 17363705 |doi= 10.1161/01.RES.0000261609.44977.25 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CD8A... {November 7, 2007 4:52:11 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 4:52:43 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:52:59 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CD8A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1akj.
| PDB = {{PDB2|1akj}}, {{PDB2|1cd8}}, {{PDB2|2hp4}}
| Name = CD8a molecule
| HGNCid = 1706
| Symbol = CD8A
| AltSymbols =; p32; CD8; Leu2; MAL
| OMIM = 186910
| ECnumber =
| Homologene = 1339
| MGIid = 88346
| GeneAtlas_image1 = PBB_GE_CD8A_205758_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015026 |text = coreceptor activity}} {{GNF_GO|id=GO:0042288 |text = MHC class I protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0042101 |text = T cell receptor complex}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0019882 |text = antigen processing and presentation}} {{GNF_GO|id=GO:0042110 |text = T cell activation}} {{GNF_GO|id=GO:0045065 |text = cytotoxic T cell differentiation}} {{GNF_GO|id=GO:0050850 |text = positive regulation of calcium-mediated signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 925
| Hs_Ensembl = ENSG00000153563
| Hs_RefseqProtein = NP_001759
| Hs_RefseqmRNA = NM_001768
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 86865245
| Hs_GenLoc_end = 86871578
| Hs_Uniprot = P01732
| Mm_EntrezGene = 12525
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_132621
| Mm_RefseqProtein = XP_132621
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''CD8a molecule''', also known as '''CD8A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified.<ref>{{cite web | title = Entrez Gene: CD8A CD8a molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=925| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Parnes JR |title=Molecular biology and function of CD4 and CD8. |journal=Adv. Immunol. |volume=44 |issue= |pages= 265-311 |year= 1989 |pmid= 2493728 |doi= }}
*{{cite journal | author=Li L, Li HS, Pauza CD, ''et al.'' |title=Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. |journal=Cell Res. |volume=15 |issue= 11-12 |pages= 923-34 |year= 2006 |pmid= 16354571 |doi= 10.1038/sj.cr.7290370 }}
*{{cite journal | author=Stove V, Verhasselt B |title=Modelling thymic HIV-1 Nef effects. |journal=Curr. HIV Res. |volume=4 |issue= 1 |pages= 57-64 |year= 2006 |pmid= 16454711 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CHRM2... {November 7, 2007 4:54:20 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:54:39 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cholinergic receptor, muscarinic 2
| HGNCid = 1951
| Symbol = CHRM2
| AltSymbols =; FLJ43243; HM2; MGC120006; MGC120007
| OMIM = 118493
| ECnumber =
| Homologene = 20190
| MGIid = 88397
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004981 |text = muscarinic acetylcholine receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007188 |text = G-protein signaling, coupled to cAMP nucleotide second messenger}} {{GNF_GO|id=GO:0007197 |text = muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway}} {{GNF_GO|id=GO:0007207 |text = muscarinic acetylcholine receptor, phospholipase C activating pathway}} {{GNF_GO|id=GO:0007213 |text = acetylcholine receptor signaling, muscarinic pathway}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0008016 |text = regulation of heart contraction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1129
| Hs_Ensembl = ENSG00000181072
| Hs_RefseqProtein = NP_000730
| Hs_RefseqmRNA = NM_000739
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 136203956
| Hs_GenLoc_end = 136355539
| Hs_Uniprot = P08172
| Mm_EntrezGene = 243764
| Mm_Ensembl = ENSMUSG00000045613
| Mm_RefseqmRNA = NM_203491
| Mm_RefseqProtein = NP_987076
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 36453362
| Mm_GenLoc_end = 36454762
| Mm_Uniprot = Q05CZ8
}}
}}
'''Cholinergic receptor, muscarinic 2''', also known as '''CHRM2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene.<ref>{{cite web | title = Entrez Gene: CHRM2 cholinergic receptor, muscarinic 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1129| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Goyal RK |title=Muscarinic receptor subtypes. Physiology and clinical implications. |journal=N. Engl. J. Med. |volume=321 |issue= 15 |pages= 1022-9 |year= 1989 |pmid= 2674717 |doi= }}
*{{cite journal | author=Brann MR, Ellis J, Jørgensen H, ''et al.'' |title=Muscarinic acetylcholine receptor subtypes: localization and structure/function. |journal=Prog. Brain Res. |volume=98 |issue= |pages= 121-7 |year= 1994 |pmid= 8248499 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CTCF... {November 7, 2007 5:12:47 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 5:13:23 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:13:31 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CTCF_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1x6h.
| PDB = {{PDB2|1x6h}}, {{PDB2|2ct1}}
| Name = CCCTC-binding factor (zinc finger protein)
| HGNCid = 13723
| Symbol = CTCF
| AltSymbols =;
| OMIM = 604167
| ECnumber =
| Homologene = 4786
| MGIid = 109447
| GeneAtlas_image1 = PBB_GE_CTCF_202521_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006349 |text = imprinting}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0010216 |text = maintenance of DNA methylation}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10664
| Hs_Ensembl = ENSG00000102974
| Hs_RefseqProtein = NP_006556
| Hs_RefseqmRNA = NM_006565
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 66153965
| Hs_GenLoc_end = 66230584
| Hs_Uniprot = P49711
| Mm_EntrezGene = 13018
| Mm_Ensembl = ENSMUSG00000005698
| Mm_RefseqmRNA = NM_007794
| Mm_RefseqProtein = NP_031820
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 108525670
| Mm_GenLoc_end = 108572051
| Mm_Uniprot = Q05CK6
}}
}}
'''CCCTC-binding factor (zinc finger protein)''', also known as '''CTCF''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.<ref>{{cite web | title = Entrez Gene: CTCF CCCTC-binding factor (zinc finger protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10664| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ohlsson R, Renkawitz R, Lobanenkov V |title=CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease. |journal=Trends Genet. |volume=17 |issue= 9 |pages= 520-7 |year= 2001 |pmid= 11525835 |doi= }}
*{{cite journal | author=Klenova EM, Morse HC, Ohlsson R, Lobanenkov VV |title=The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer. |journal=Semin. Cancer Biol. |volume=12 |issue= 5 |pages= 399-414 |year= 2003 |pmid= 12191639 |doi= }}
*{{cite journal | author=Kuhn EJ, Geyer PK |title=Genomic insulators: connecting properties to mechanism. |journal=Curr. Opin. Cell Biol. |volume=15 |issue= 3 |pages= 259-65 |year= 2004 |pmid= 12787766 |doi= }}
*{{cite journal | author=Recillas-Targa F, De La Rosa-Velázquez IA, Soto-Reyes E, Benítez-Bribiesca L |title=Epigenetic boundaries of tumour suppressor gene promoters: the CTCF connection and its role in carcinogenesis. |journal=J. Cell. Mol. Med. |volume=10 |issue= 3 |pages= 554-68 |year= 2007 |pmid= 16989720 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CYP27B1... {November 7, 2007 4:54:39 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:55:27 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cytochrome P450, family 27, subfamily B, polypeptide 1
| HGNCid = 2606
| Symbol = CYP27B1
| AltSymbols =; CYP1; CP2B; CYP1alpha; CYP27B; P450c1; PDDR; VDD1; VDDR; VDDRI; VDR
| OMIM = 609506
| ECnumber =
| Homologene = 37139
| MGIid = 1098274
| GeneAtlas_image1 = PBB_GE_CYP27B1_205676_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0004498 |text = calcidiol 1-monooxygenase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0019825 |text = oxygen binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0006874 |text = cellular calcium ion homeostasis}} {{GNF_GO|id=GO:0009110 |text = vitamin biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1594
| Hs_Ensembl = ENSG00000111012
| Hs_RefseqProtein = NP_000776
| Hs_RefseqmRNA = NM_000785
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 56442385
| Hs_GenLoc_end = 56447243
| Hs_Uniprot = O15528
| Mm_EntrezGene = 13115
| Mm_Ensembl = ENSMUSG00000006724
| Mm_RefseqmRNA = NM_010009
| Mm_RefseqProtein = NP_034139
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 126451199
| Mm_GenLoc_end = 126455954
| Mm_Uniprot = Q66JY8
}}
}}
'''Cytochrome P450, family 27, subfamily B, polypeptide 1''', also known as '''CYP27B1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.<ref>{{cite web | title = Entrez Gene: CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1594| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DNMT3B... {November 7, 2007 4:55:27 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 4:55:59 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:56:12 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_DNMT3B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1khc.
| PDB = {{PDB2|1khc}}
| Name = DNA (cytosine-5-)-methyltransferase 3 beta
| HGNCid = 2979
| Symbol = DNMT3B
| AltSymbols =; ICF; M.HsaIIIB
| OMIM = 602900
| ECnumber =
| Homologene = 56000
| MGIid = 1261819
| GeneAtlas_image1 = PBB_GE_DNMT3B_220668_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003886 |text = DNA (cytosine-5-)-methyltransferase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008168 |text = methyltransferase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0008326 |text = site-specific DNA-methyltransferase (cytosine-specific) activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005720 |text = nuclear heterochromatin}}
| Process = {{GNF_GO|id=GO:0006306 |text = DNA methylation}} {{GNF_GO|id=GO:0006349 |text = imprinting}} {{GNF_GO|id=GO:0031503 |text = protein complex localization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1789
| Hs_Ensembl = ENSG00000088305
| Hs_RefseqProtein = NP_008823
| Hs_RefseqmRNA = NM_006892
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 30813852
| Hs_GenLoc_end = 30860823
| Hs_Uniprot = Q9UBC3
| Mm_EntrezGene = 13436
| Mm_Ensembl = ENSMUSG00000027478
| Mm_RefseqmRNA = XM_001003158
| Mm_RefseqProtein = XP_001003158
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 153340894
| Mm_GenLoc_end = 153379171
| Mm_Uniprot = O88509
}}
}}
'''DNA (cytosine-5-)-methyltransferase 3 beta''', also known as '''DNMT3B''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.<ref>{{cite web | title = Entrez Gene: DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1789| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wijmenga C, Hansen RS, Gimelli G, ''et al.'' |title=Genetic variation in ICF syndrome: evidence for genetic heterogeneity. |journal=Hum. Mutat. |volume=16 |issue= 6 |pages= 509-17 |year= 2001 |pmid= 11102980 |doi= 10.1002/1098-1004(200012)16:6<509::AID-HUMU8>3.0.CO;2-V }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ENO1... {November 7, 2007 4:56:12 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:57:08 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Enolase 1, (alpha)
| HGNCid = 3350
| Symbol = ENO1
| AltSymbols =; ENO1L1; MBP-1; MPB1; NNE; PPH
| OMIM = 172430
| ECnumber =
| Homologene = 68183
| MGIid = 95393
| GeneAtlas_image1 = PBB_GE_ENO1_201231_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ENO1_217294_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0004634 |text = phosphopyruvate hydratase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008243 |text = plasminogen activator activity}} {{GNF_GO|id=GO:0016829 |text = lyase activity}}
| Component = {{GNF_GO|id=GO:0000015 |text = phosphopyruvate hydratase complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006096 |text = glycolysis}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0030308 |text = negative regulation of cell growth}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2023
| Hs_Ensembl = ENSG00000074800
| Hs_RefseqProtein = NP_001419
| Hs_RefseqmRNA = NM_001428
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 8843648
| Hs_GenLoc_end = 8978713
| Hs_Uniprot = P06733
| Mm_EntrezGene = 13806
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_001006583
| Mm_RefseqProtein = XP_001006583
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Enolase 1, (alpha)''', also known as '''ENO1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of three enolase isoenzymes found in mammals; it encodes alpha-enolase, a homodimeric soluble enzyme, and also encodes a shorter monomeric structural lens protein, tau-crystallin. The two proteins are made from the same message. The full length protein, the isoenzyme, is found in the cytoplasm. The shorter protein is produced from an alternative translation start, is localized to the nucleus, and has been found to bind to an element in the c-myc promoter. A pseudogene has been identified that is located on the other arm of the same chromosome.<ref>{{cite web | title = Entrez Gene: ENO1 enolase 1, (alpha)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2023| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Pancholi V |title=Multifunctional alpha-enolase: its role in diseases. |journal=Cell. Mol. Life Sci. |volume=58 |issue= 7 |pages= 902-20 |year= 2001 |pmid= 11497239 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GAB1... {November 7, 2007 4:57:08 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 4:57:42 PM PST}
- CREATED: Created new protein page: GAB1 {November 7, 2007 4:57:49 PM PST}
- INFO: Beginning work on GATA3... {November 7, 2007 4:57:49 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 4:59:56 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = GATA binding protein 3
| HGNCid = 4172
| Symbol = GATA3
| AltSymbols =; HDR; MGC2346; MGC5199; MGC5445
| OMIM = 131320
| ECnumber =
| Homologene = 1550
| MGIid = 95663
| GeneAtlas_image1 = PBB_GE_GATA3_209604_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GATA3_209602_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_GATA3_209603_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2625
| Hs_Ensembl = ENSG00000107485
| Hs_RefseqProtein = NP_001002295
| Hs_RefseqmRNA = NM_001002295
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 8136662
| Hs_GenLoc_end = 8157170
| Hs_Uniprot = P23771
| Mm_EntrezGene = 14462
| Mm_Ensembl = ENSMUSG00000015619
| Mm_RefseqmRNA = NM_008091
| Mm_RefseqProtein = NP_032117
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 9774921
| Mm_GenLoc_end = 9796453
| Mm_Uniprot = Q3TZD6
}}
}}
'''GATA binding protein 3''', also known as '''GATA3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Naylor MJ, Ormandy CJ |title=Gata-3 and mammary cell fate. |journal=Breast Cancer Res. |volume=9 |issue= 2 |pages= 302 |year= 2007 |pmid= 17381824 |doi= 10.1186/bcr1661 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GATA4... {November 7, 2007 4:59:56 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 5:00:30 PM PST}
- CREATED: Created new protein page: GATA4 {November 7, 2007 5:00:37 PM PST}
- INFO: Beginning work on GPX1... {November 7, 2007 5:00:37 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 5:00:52 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 5:01:06 PM PST}
- CREATED: Created new protein page: GPX1 {November 7, 2007 5:01:14 PM PST}
- INFO: Beginning work on ID2... {November 7, 2007 5:01:14 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 5:03:35 PM PST}
- CREATED: Created new protein page: ID2 {November 7, 2007 5:03:50 PM PST}
- INFO: Beginning work on IQGAP1... {November 7, 2007 5:11:22 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 5:12:32 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:12:47 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_IQGAP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1x0h.
| PDB = {{PDB2|1x0h}}
| Name = IQ motif containing GTPase activating protein 1
| HGNCid = 6110
| Symbol = IQGAP1
| AltSymbols =; HUMORFA01; KIAA0051; SAR1; p195
| OMIM = 603379
| ECnumber =
| Homologene = 74514
| MGIid = 1352757
| GeneAtlas_image1 = PBB_GE_IQGAP1_210840_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_IQGAP1_200791_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_IQGAP1_213446_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005095 |text = GTPase inhibitor activity}} {{GNF_GO|id=GO:0005099 |text = Ras GTPase activator activity}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005884 |text = actin filament}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0046580 |text = negative regulation of Ras protein signal transduction}} {{GNF_GO|id=GO:0051056 |text = regulation of small GTPase mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8826
| Hs_Ensembl = ENSG00000140575
| Hs_RefseqProtein = NP_003861
| Hs_RefseqmRNA = NM_003870
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 88732477
| Hs_GenLoc_end = 88846479
| Hs_Uniprot = P46940
| Mm_EntrezGene = 29875
| Mm_Ensembl = ENSMUSG00000030536
| Mm_RefseqmRNA = NM_016721
| Mm_RefseqProtein = NP_057930
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 80586294
| Mm_GenLoc_end = 80676807
| Mm_Uniprot = Q05CQ4
}}
}}
'''IQ motif containing GTPase activating protein 1''', also known as '''IQGAP1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.<ref>{{cite web | title = Entrez Gene: IQGAP1 IQ motif containing GTPase activating protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8826| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tirnauer JS |title=A new cytoskeletal connection for APC: linked to actin through IQGAP. |journal=Dev. Cell |volume=7 |issue= 6 |pages= 778-80 |year= 2005 |pmid= 15572120 |doi= 10.1016/j.devcel.2004.11.012 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KRT1... {November 7, 2007 5:03:50 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:04:27 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Keratin 1 (epidermolytic hyperkeratosis)
| HGNCid = 6412
| Symbol = KRT1
| AltSymbols =; CK1; EHK1; K1; KRT1A
| OMIM = 139350
| ECnumber =
| Homologene = 38146
| MGIid = 96698
| GeneAtlas_image1 = PBB_GE_KRT1_205900_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}}
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005882 |text = intermediate filament}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001867 |text = complement activation, lectin pathway}} {{GNF_GO|id=GO:0006979 |text = response to oxidative stress}} {{GNF_GO|id=GO:0008544 |text = epidermis development}} {{GNF_GO|id=GO:0042730 |text = fibrinolysis}} {{GNF_GO|id=GO:0045765 |text = regulation of angiogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3848
| Hs_Ensembl = ENSG00000167768
| Hs_RefseqProtein = NP_006112
| Hs_RefseqmRNA = NM_006121
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 51354719
| Hs_GenLoc_end = 51360446
| Hs_Uniprot = P04264
| Mm_EntrezGene = 16678
| Mm_Ensembl = ENSMUSG00000046834
| Mm_RefseqmRNA = NM_008473
| Mm_RefseqProtein = NP_032499
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 101673462
| Mm_GenLoc_end = 101678828
| Mm_Uniprot = P04104
}}
}}
'''Keratin 1 (epidermolytic hyperkeratosis)''', also known as '''KRT1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.<ref>{{cite web | title = Entrez Gene: KRT1 keratin 1 (epidermolytic hyperkeratosis)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3848| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Whittock NV, Ashton GH, Griffiths WA, ''et al.'' |title=New mutations in keratin 1 that cause bullous congenital ichthyosiform erythroderma and keratin 2e that cause ichthyosis bullosa of Siemens. |journal=Br. J. Dermatol. |volume=145 |issue= 2 |pages= 330-5 |year= 2001 |pmid= 11531804 |doi= }}
*{{cite journal | author=Langbein L, Schweizer J |title=Keratins of the human hair follicle. |journal=Int. Rev. Cytol. |volume=243 |issue= |pages= 1-78 |year= 2005 |pmid= 15797458 |doi= 10.1016/S0074-7696(05)43001-6 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PIAS1... {November 7, 2007 5:10:24 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 5:11:03 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:11:22 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PIAS1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1v66.
| PDB = {{PDB2|1v66}}
| Name = Protein inhibitor of activated STAT, 1
| HGNCid = 2752
| Symbol = PIAS1
| AltSymbols =; GBP; DDXBP1; GU/RH-II; MGC141878; MGC141879; ZMIZ3
| OMIM = 603566
| ECnumber =
| Homologene = 22953
| MGIid = 1913125
| GeneAtlas_image1 = PBB_GE_PIAS1_217864_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0004004 |text = ATP-dependent RNA helicase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050681 |text = androgen receptor binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007259 |text = JAK-STAT cascade}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8554
| Hs_Ensembl = ENSG00000033800
| Hs_RefseqProtein = NP_057250
| Hs_RefseqmRNA = NM_016166
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 66165695
| Hs_GenLoc_end = 66267392
| Hs_Uniprot = O75925
| Mm_EntrezGene = 56469
| Mm_Ensembl = ENSMUSG00000032405
| Mm_RefseqmRNA = NM_019663
| Mm_RefseqProtein = NP_062637
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 62679132
| Mm_GenLoc_end = 62778885
| Mm_Uniprot = Q2M4G9
}}
}}
'''Protein inhibitor of activated STAT, 1''', also known as '''PIAS1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.<ref>{{cite web | title = Entrez Gene: PIAS1 protein inhibitor of activated STAT, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8554| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PPARBP... {November 7, 2007 5:04:27 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:05:47 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = PPAR binding protein
| HGNCid = 9234
| Symbol = PPARBP
| AltSymbols =; PBP; CRSP1; CRSP200; DRIP205; DRIP230; MED1; MGC71488; PPARGBP; RB18A; TRAP220; TRIP2
| OMIM = 604311
| ECnumber =
| Homologene = 21002
| MGIid = 1100846
| GeneAtlas_image1 = PBB_GE_PPARBP_203497_at_tn.png
| GeneAtlas_image2 = PBB_GE_PPARBP_203496_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016455 |text = RNA polymerase II transcription mediator activity}} {{GNF_GO|id=GO:0030374 |text = ligand-dependent nuclear receptor transcription coactivator activity}} {{GNF_GO|id=GO:0031177 |text = phosphopantetheine binding}} {{GNF_GO|id=GO:0042809 |text = vitamin D receptor binding}} {{GNF_GO|id=GO:0046966 |text = thyroid hormone receptor binding}}
| Component = {{GNF_GO|id=GO:0000119 |text = mediator complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001701 |text = in utero embryonic development}} {{GNF_GO|id=GO:0001889 |text = liver development}} {{GNF_GO|id=GO:0001892 |text = embryonic placenta development}} {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006367 |text = transcription initiation from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006590 |text = thyroid hormone generation}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007420 |text = brain development}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0035050 |text = embryonic heart tube development}} {{GNF_GO|id=GO:0035116 |text = embryonic hindlimb morphogenesis}} {{GNF_GO|id=GO:0035162 |text = embryonic hemopoiesis}} {{GNF_GO|id=GO:0045444 |text = fat cell differentiation}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5469
| Hs_Ensembl = ENSG00000125686
| Hs_RefseqProtein = NP_004765
| Hs_RefseqmRNA = NM_004774
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 34816380
| Hs_GenLoc_end = 34861030
| Hs_Uniprot = Q15648
| Mm_EntrezGene = 19014
| Mm_Ensembl = ENSMUSG00000018160
| Mm_RefseqmRNA = NM_001080118
| Mm_RefseqProtein = NP_001073587
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 97968244
| Mm_GenLoc_end = 98009350
| Mm_Uniprot = Q925J9
}}
}}
'''PPAR binding protein''', also known as '''PPARBP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize.<ref>{{cite web | title = Entrez Gene: PPARBP PPAR binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5469| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SLPI... {November 7, 2007 5:05:47 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:06:59 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Secretory leukocyte peptidase inhibitor
| HGNCid = 11092
| Symbol = SLPI
| AltSymbols =; ALK1; ALP; MPI; BLPI; HUSI; HUSI-I; WAP4; WFDC4
| OMIM = 107285
| ECnumber =
| Homologene = 2305
| MGIid = 109297
| GeneAtlas_image1 = PBB_GE_SLPI_203021_at_tn.png
| Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}}
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6590
| Hs_Ensembl = ENSG00000124107
| Hs_RefseqProtein = NP_003055
| Hs_RefseqmRNA = NM_003064
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 43314293
| Hs_GenLoc_end = 43316620
| Hs_Uniprot = P03973
| Mm_EntrezGene = 20568
| Mm_Ensembl = ENSMUSG00000017002
| Mm_RefseqmRNA = NM_011414
| Mm_RefseqProtein = NP_035544
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 164045509
| Mm_GenLoc_end = 164064151
| Mm_Uniprot = Q548X8
}}
}}
'''Secretory leukocyte peptidase inhibitor''', also known as '''SLPI''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes; the protein is also thought to have broad-spectrum anti-biotic activity.<ref>{{cite web | title = Entrez Gene: SLPI secretory leukocyte peptidase inhibitor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6590| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Fritz H |title=Human mucus proteinase inhibitor (human MPI). Human seminal inhibitor I (HUSI-I), antileukoprotease (ALP), secretory leukocyte protease inhibitor (SLPI). |journal=Biol. Chem. Hoppe-Seyler |volume=369 Suppl |issue= |pages= 79-82 |year= 1989 |pmid= 3060147 |doi= }}
*{{cite journal | author=Sallenave JM |title=The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease. |journal=Respir. Res. |volume=1 |issue= 2 |pages= 87-92 |year= 2003 |pmid= 11667971 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SREBF2... {November 7, 2007 5:06:59 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 5:07:16 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 5:07:26 PM PST}
- CREATED: Created new protein page: SREBF2 {November 7, 2007 5:07:34 PM PST}
- INFO: Beginning work on STAT2... {November 7, 2007 5:07:34 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:08:49 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Signal transducer and activator of transcription 2, 113kDa
| HGNCid = 11363
| Symbol = STAT2
| AltSymbols =; ISGF-3; MGC59816; P113; STAT113
| OMIM = 600556
| ECnumber =
| Homologene = 3952
| MGIid = 103039
| GeneAtlas_image1 = PBB_GE_STAT2_205170_at_tn.png
| GeneAtlas_image2 = PBB_GE_STAT2_217199_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005062 |text = hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007259 |text = JAK-STAT cascade}} {{GNF_GO|id=GO:0009615 |text = response to virus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6773
| Hs_Ensembl = ENSG00000170581
| Hs_RefseqProtein = NP_005410
| Hs_RefseqmRNA = NM_005419
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 55021651
| Hs_GenLoc_end = 55040176
| Hs_Uniprot = P52630
| Mm_EntrezGene = 20847
| Mm_Ensembl = ENSMUSG00000040033
| Mm_RefseqmRNA = XM_990913
| Mm_RefseqProtein = XP_996007
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 127673525
| Mm_GenLoc_end = 127695798
| Mm_Uniprot =
}}
}}
'''Signal transducer and activator of transcription 2, 113kDa''', also known as '''STAT2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.<ref>{{cite web | title = Entrez Gene: STAT2 signal transducer and activator of transcription 2, 113kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6773| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Cebulla CM, Miller DM, Sedmak DD |title=Viral inhibition of interferon signal transduction. |journal=Intervirology |volume=42 |issue= 5-6 |pages= 325-30 |year= 2000 |pmid= 10702714 |doi= }}
*{{cite journal | author=Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW |title=Signaling through the JAK/STAT pathway, recent advances and future challenges. |journal=Gene |volume=285 |issue= 1-2 |pages= 1-24 |year= 2002 |pmid= 12039028 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on UNG... {November 7, 2007 5:08:49 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 5:09:24 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:09:45 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_UNG_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1akz.
| PDB = {{PDB2|1akz}}, {{PDB2|1emh}}, {{PDB2|1emj}}, {{PDB2|1q3f}}, {{PDB2|1ssp}}, {{PDB2|1ugh}}, {{PDB2|1yuo}}, {{PDB2|2hxm}}, {{PDB2|2ssp}}, {{PDB2|4skn}}
| Name = Uracil-DNA glycosylase
| HGNCid = 12572
| Symbol = UNG
| AltSymbols =; DGU; DKFZp781L1143; HIGM4; UDG; UNG1; UNG15
| OMIM = 191525
| ECnumber =
| Homologene = 6585
| MGIid = 109352
| GeneAtlas_image1 = PBB_GE_UNG_202330_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004844 |text = uracil DNA N-glycosylase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016798 |text = hydrolase activity, acting on glycosyl bonds}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0006284 |text = base-excision repair}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0016446 |text = somatic hypermutation of immunoglobulin genes}} {{GNF_GO|id=GO:0016447 |text = somatic recombination of immunoglobulin gene segments}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7374
| Hs_Ensembl = ENSG00000076248
| Hs_RefseqProtein = NP_003353
| Hs_RefseqmRNA = NM_003362
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 108019798
| Hs_GenLoc_end = 108033181
| Hs_Uniprot = P13051
| Mm_EntrezGene = 22256
| Mm_Ensembl = ENSMUSG00000029591
| Mm_RefseqmRNA = NM_001040691
| Mm_RefseqProtein = NP_001035781
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 114391376
| Mm_GenLoc_end = 114400320
| Mm_Uniprot = Q99KR9
}}
}}
'''Uracil-DNA glycosylase''', also known as '''UNG''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2.<ref>{{cite web | title = Entrez Gene: UNG uracil-DNA glycosylase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7374| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Caradonna S, Muller-Weeks S |title=The nature of enzymes involved in uracil-DNA repair: isoform characteristics of proteins responsible for nuclear and mitochondrial genomic integrity. |journal=Curr. Protein Pept. Sci. |volume=2 |issue= 4 |pages= 335-47 |year= 2002 |pmid= 12369930 |doi= }}
*{{cite journal | author=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193-205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789 }}
*{{cite journal | author=Van Maele B, Debyser Z |title=HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins. |journal=AIDS reviews |volume=7 |issue= 1 |pages= 26-43 |year= 2005 |pmid= 15875659 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on VASP... {November 7, 2007 5:09:45 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 5:10:16 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:10:24 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_VASP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1egx.
| PDB = {{PDB2|1egx}}, {{PDB2|1usd}}, {{PDB2|1use}}
| Name = Vasodilator-stimulated phosphoprotein
| HGNCid = 12652
| Symbol = VASP
| AltSymbols =;
| OMIM = 601703
| ECnumber =
| Homologene = 7592
| MGIid = 109268
| GeneAtlas_image1 = PBB_GE_VASP_202205_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}}
| Component = {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7408
| Hs_Ensembl = ENSG00000125753
| Hs_RefseqProtein = NP_001008736
| Hs_RefseqmRNA = NM_001008736
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 50702528
| Hs_GenLoc_end = 50722076
| Hs_Uniprot = P50552
| Mm_EntrezGene = 22323
| Mm_Ensembl = ENSMUSG00000030403
| Mm_RefseqmRNA = NM_009499
| Mm_RefseqProtein = NP_033525
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 18416239
| Mm_GenLoc_end = 18423349
| Mm_Uniprot = P70460
}}
}}
'''Vasodilator-stimulated phosphoprotein''', also known as '''VASP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.<ref>{{cite web | title = Entrez Gene: VASP vasodilator-stimulated phosphoprotein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7408| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
end log.
