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Log page index: User:ProteinBoxBot/PBB_Log_Index
[edit] Protein Status Quick Log - Date: 23:11, 7 November 2007 (UTC)
[edit] Proteins without matches (13)
[edit] Proteins with a High Potential Match (12)
[edit] Created (5)
[edit] Manual Inspection (Page not found) (20)
[edit] Protein Status Grid - Date: 23:11, 7 November 2007 (UTC)
[edit] Vebose Log - Date: 23:11, 7 November 2007 (UTC)
- INFO: Beginning work on ABCA4... {November 7, 2007 2:39:33 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:40:21 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = ATP-binding cassette, sub-family A (ABC1), member 4
| HGNCid = 34
| Symbol = ABCA4
| AltSymbols =; ABC10; ABCR; ARMD2; CORD3; DKFZp781N1972; FFM; RMP; RP19; STGD; STGD1
| OMIM = 601691
| ECnumber =
| Homologene = 298
| MGIid = 109424
| GeneAtlas_image1 = PBB_GE_ABCA4_210082_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0042626 |text = ATPase activity, coupled to transmembrane movement of substances}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0007603 |text = phototransduction, visible light}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 24
| Hs_Ensembl = ENSG00000198691
| Hs_RefseqProtein = NP_000341
| Hs_RefseqmRNA = NM_000350
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 94230981
| Hs_GenLoc_end = 94359279
| Hs_Uniprot = P78363
| Mm_EntrezGene = 11304
| Mm_Ensembl = ENSMUSG00000028125
| Mm_RefseqmRNA = NM_007378
| Mm_RefseqProtein = NP_031404
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 122036482
| Mm_GenLoc_end = 122172083
| Mm_Uniprot = Q3TLK5
}}
}}
'''ATP-binding cassette, sub-family A (ABC1), member 4''', also known as '''ABCA4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and macular degeneration age-related 2.<ref>{{cite web | title = Entrez Gene: ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=24| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=MacDonald IM |title=Genetic aspects of age-related macular degeneration. |journal=Can. J. Ophthalmol. |volume=40 |issue= 3 |pages= 288-92 |year= 2006 |pmid= 15947798 |doi= 10.1139/i05-002 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ADRB1... {November 7, 2007 2:40:21 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:41:17 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Adrenergic, beta-1-, receptor
| HGNCid = 285
| Symbol = ADRB1
| AltSymbols =; ADRB1R; B1AR; BETA1AR; RHR
| OMIM = 109630
| ECnumber =
| Homologene = 20171
| MGIid = 87937
| GeneAtlas_image1 = PBB_GE_ADRB1_208214_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004935 |text = adrenoceptor activity}} {{GNF_GO|id=GO:0004940 |text = beta1-adrenergic receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001996 |text = positive regulation of heart contraction rate by epinephrine-norepinephrine}} {{GNF_GO|id=GO:0001997 |text = increased strength of heart contraction by epinephrine-norepinephrine}} {{GNF_GO|id=GO:0002024 |text = diet induced thermogenesis}} {{GNF_GO|id=GO:0002025 |text = norepinephrine-epinephrine vasodilation during regulation of blood pressure}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007190 |text = adenylate cyclase activation}} {{GNF_GO|id=GO:0009409 |text = response to cold}} {{GNF_GO|id=GO:0031649 |text = heat generation}} {{GNF_GO|id=GO:0040015 |text = negative regulation of body size}} {{GNF_GO|id=GO:0042596 |text = fear response}} {{GNF_GO|id=GO:0050873 |text = brown fat cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 153
| Hs_Ensembl = ENSG00000043591
| Hs_RefseqProtein = NP_000675
| Hs_RefseqmRNA = NM_000684
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 115793796
| Hs_GenLoc_end = 115796657
| Hs_Uniprot = P08588
| Mm_EntrezGene = 11554
| Mm_Ensembl = ENSMUSG00000035283
| Mm_RefseqmRNA = NM_007419
| Mm_RefseqProtein = NP_031445
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 56775622
| Mm_GenLoc_end = 56777022
| Mm_Uniprot = Q9CRR2
}}
}}
'''Adrenergic, beta-1-, receptor''', also known as '''ADRB1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure.<ref>{{cite web | title = Entrez Gene: ADRB1 adrenergic, beta-1-, receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=153| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Frielle T, Kobilka B, Lefkowitz RJ, Caron MG |title=Human beta 1- and beta 2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes. |journal=Trends Neurosci. |volume=11 |issue= 7 |pages= 321-4 |year= 1989 |pmid= 2465637 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ARNT... {November 7, 2007 2:41:17 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 2:42:29 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:42:46 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ARNT_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1x0o.
| PDB = {{PDB2|1x0o}}, {{PDB2|2a24}}, {{PDB2|2b02}}
| Name = Aryl hydrocarbon receptor nuclear translocator
| HGNCid = 700
| Symbol = ARNT
| AltSymbols =; HIF-1beta; HIF1B; HIF1BETA; TANGO
| OMIM = 126110
| ECnumber =
| Homologene = 1261
| MGIid = 88071
| GeneAtlas_image1 = PBB_GE_ARNT_218221_at_tn.png
| GeneAtlas_image2 = PBB_GE_ARNT_210828_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_ARNT_218222_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005061 |text = aryl hydrocarbon receptor nuclear translocator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000060 |text = protein import into nucleus, translocation}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 405
| Hs_Ensembl = ENSG00000143437
| Hs_RefseqProtein = NP_001659
| Hs_RefseqmRNA = NM_001668
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 149048810
| Hs_GenLoc_end = 149115837
| Hs_Uniprot = P27540
| Mm_EntrezGene = 11863
| Mm_Ensembl = ENSMUSG00000015522
| Mm_RefseqmRNA = NM_001037737
| Mm_RefseqProtein = NP_001032826
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 95519792
| Mm_GenLoc_end = 95581692
| Mm_Uniprot = Q3U7X2
}}
}}
'''Aryl hydrocarbon receptor nuclear translocator''', also known as '''ARNT''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene.<ref>{{cite web | title = Entrez Gene: ARNT aryl hydrocarbon receptor nuclear translocator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=405| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Haase VH |title=Hypoxia-inducible factors in the kidney. |journal=Am. J. Physiol. Renal Physiol. |volume=291 |issue= 2 |pages= F271-81 |year= 2006 |pmid= 16554418 |doi= 10.1152/ajprenal.00071.2006 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CCR1... {November 7, 2007 2:42:46 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 2:43:48 PM PST}
- CREATED: Created new protein page: CCR1 {November 7, 2007 2:43:57 PM PST}
- INFO: Beginning work on CSF2RB... {November 7, 2007 2:43:57 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 2:44:32 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:44:48 PM PST}
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{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CSF2RB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1c8p.
| PDB = {{PDB2|1c8p}}, {{PDB2|1egj}}, {{PDB2|1gh7}}, {{PDB2|2gys}}
| Name = Colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
| HGNCid = 2436
| Symbol = CSF2RB
| AltSymbols =; CD131; CDw131; IL3RB; IL5RB
| OMIM = 138981
| ECnumber =
| Homologene = 339
| MGIid = 1339759
| GeneAtlas_image1 = PBB_GE_CSF2RB_205159_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004912 |text = interleukin-3 receptor activity}} {{GNF_GO|id=GO:0004914 |text = interleukin-5 receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0030526 |text = granulocyte macrophage colony-stimulating factor receptor complex}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007585 |text = respiratory gaseous exchange}} {{GNF_GO|id=GO:0019221 |text = cytokine and chemokine mediated signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1439
| Hs_Ensembl = ENSG00000100368
| Hs_RefseqProtein = NP_000386
| Hs_RefseqmRNA = NM_000395
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 22
| Hs_GenLoc_start = 35648168
| Hs_GenLoc_end = 35664764
| Hs_Uniprot = P32927
| Mm_EntrezGene = 12983
| Mm_Ensembl = ENSMUSG00000071713
| Mm_RefseqmRNA = NM_007780
| Mm_RefseqProtein = NP_031806
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 78153275
| Mm_GenLoc_end = 78177290
| Mm_Uniprot = Q3TB34
}}
}}
'''Colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)''', also known as '''CSF2RB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = CSF2RB is a common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defective CSF2RB has been reported to be associated with protein alveolar proteinosis<ref>{{cite web | title = Entrez Gene: CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1439| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CXCL1... {November 7, 2007 2:50:59 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 2:51:12 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:51:36 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CXCL1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mgs.
| PDB = {{PDB2|1mgs}}, {{PDB2|1msg}}, {{PDB2|1msh}}
| Name = Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
| HGNCid = 4602
| Symbol = CXCL1
| AltSymbols =; GRO1; GROa; MGSA; MGSA alpha; MGSA-a; NAP-3; SCYB1
| OMIM = 155730
| ECnumber =
| Homologene = 84701
| MGIid = 3037818
| Function = {{GNF_GO|id=GO:0008009 |text = chemokine activity}} {{GNF_GO|id=GO:0008047 |text = enzyme activator activity}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0030036 |text = actin cytoskeleton organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2919
| Hs_Ensembl = ENSG00000163739
| Hs_RefseqProtein = NP_001502
| Hs_RefseqmRNA = NM_001511
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 74953973
| Hs_GenLoc_end = 74968249
| Hs_Uniprot = P09341
| Mm_EntrezGene = 330122
| Mm_Ensembl = ENSMUSG00000029379
| Mm_RefseqmRNA = NM_203320
| Mm_RefseqProtein = NP_976065
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 91861303
| Mm_GenLoc_end = 91863293
| Mm_Uniprot =
}}
}}
'''Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)''', also known as '''CXCL1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CXC chemokines are further subdivided into ELR and non-ELR types based on the presence or absence of a glu-leu-arg sequence adjacent and N terminal to the CXC motif.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2919| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DRD3... {November 7, 2007 2:44:48 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:46:11 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Dopamine receptor D3
| HGNCid = 3024
| Symbol = DRD3
| AltSymbols =; D3DR; ETM1; FET1; MGC149204; MGC149205
| OMIM = 126451
| ECnumber =
| Homologene = 623
| MGIid = 94925
| GeneAtlas_image1 = PBB_GE_DRD3_211625_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_DRD3_214559_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004952 |text = dopamine receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007212 |text = dopamine receptor signaling pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007610 |text = behavior}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1814
| Hs_Ensembl = ENSG00000151577
| Hs_RefseqProtein = NP_000787
| Hs_RefseqmRNA = NM_000796
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 115330247
| Hs_GenLoc_end = 115380446
| Hs_Uniprot = P35462
| Mm_EntrezGene = 13490
| Mm_Ensembl = ENSMUSG00000022705
| Mm_RefseqmRNA = NM_007877
| Mm_RefseqProtein = NP_031903
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 43681574
| Mm_GenLoc_end = 43742171
| Mm_Uniprot = Q0VEC4
}}
}}
'''Dopamine receptor D3''', also known as '''DRD3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the D3 subtype of the dopamine receptor. The D3 subtype inhibits adenylyl cyclase through inhibitory G-proteins. This receptor is expressed in phylogenetically older regions of the brain, suggesting that this receptor plays a role in cognitive and emotional functions. It is a target for drugs which treat schizophrenia, drug addiction, and Parkinson disease. Alternative splicing of this gene results in multiple transcript variants that would encode different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).<ref>{{cite web | title = Entrez Gene: DRD3 dopamine receptor D3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1814| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Missale C, Nash SR, Robinson SW, ''et al.'' |title=Dopamine receptors: from structure to function. |journal=Physiol. Rev. |volume=78 |issue= 1 |pages= 189-225 |year= 1998 |pmid= 9457173 |doi= }}
*{{cite journal | author=Sidhu A, Niznik HB |title=Coupling of dopamine receptor subtypes to multiple and diverse G proteins. |journal=Int. J. Dev. Neurosci. |volume=18 |issue= 7 |pages= 669-77 |year= 2000 |pmid= 10978845 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on E2F4... {November 7, 2007 2:46:11 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 2:47:02 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 2:47:12 PM PST}
- CREATED: Created new protein page: E2F4 {November 7, 2007 2:47:20 PM PST}
- INFO: Beginning work on EDNRA... {November 7, 2007 2:47:20 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:48:33 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Endothelin receptor type A
| HGNCid = 3179
| Symbol = EDNRA
| AltSymbols =; ETA; ETRA
| OMIM = 131243
| ECnumber =
| Homologene = 1478
| MGIid = 105923
| GeneAtlas_image1 = PBB_GE_EDNRA_204464_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_EDNRA_204463_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_EDNRA_216235_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0001599 |text = endothelin-A receptor activity}} {{GNF_GO|id=GO:0004435 |text = phosphoinositide phospholipase C activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001569 |text = patterning of blood vessels}} {{GNF_GO|id=GO:0001666 |text = response to hypoxia}} {{GNF_GO|id=GO:0001701 |text = in utero embryonic development}} {{GNF_GO|id=GO:0006939 |text = smooth muscle contraction}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007190 |text = adenylate cyclase activation}} {{GNF_GO|id=GO:0007202 |text = phospholipase C activation}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0007585 |text = respiratory gaseous exchange}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0014032 |text = neural crest cell development}} {{GNF_GO|id=GO:0015758 |text = glucose transport}} {{GNF_GO|id=GO:0030818 |text = negative regulation of cAMP biosynthetic process}} {{GNF_GO|id=GO:0042310 |text = vasoconstriction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1909
| Hs_Ensembl = ENSG00000151617
| Hs_RefseqProtein = NP_001948
| Hs_RefseqmRNA = NM_001957
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 148621575
| Hs_GenLoc_end = 148685555
| Hs_Uniprot = P25101
| Mm_EntrezGene = 13617
| Mm_Ensembl = ENSMUSG00000031616
| Mm_RefseqmRNA = NM_010332
| Mm_RefseqProtein = NP_034462
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 80559103
| Mm_GenLoc_end = 80620420
| Mm_Uniprot = Q61614
}}
}}
'''Endothelin receptor type A''', also known as '''EDNRA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EMD... {November 7, 2007 2:48:33 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 2:49:10 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:49:23 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_EMD_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jei.
| PDB = {{PDB2|1jei}}, {{PDB2|2odc}}, {{PDB2|2odg}}
| Name = Emerin (Emery-Dreifuss muscular dystrophy)
| HGNCid = 3331
| Symbol = EMD
| AltSymbols =; EDMD; STA
| OMIM = 300384
| ECnumber =
| Homologene = 91
| MGIid = 108117
| GeneAtlas_image1 = PBB_GE_EMD_209477_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005635 |text = nuclear envelope}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0007517 |text = muscle development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2010
| Hs_Ensembl = ENSG00000102119
| Hs_RefseqProtein = NP_000108
| Hs_RefseqmRNA = NM_000117
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 153260751
| Hs_GenLoc_end = 153263077
| Hs_Uniprot = P50402
| Mm_EntrezGene = 13726
| Mm_Ensembl = ENSMUSG00000001964
| Mm_RefseqmRNA = NM_007927
| Mm_RefseqProtein = NP_031953
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 70507559
| Mm_GenLoc_end = 70513529
| Mm_Uniprot = Q3TIH6
}}
}}
'''Emerin (Emery-Dreifuss muscular dystrophy)''', also known as '''EMD''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene.<ref>{{cite web | title = Entrez Gene: EMD emerin (Emery-Dreifuss muscular dystrophy)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2010| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Gant TM, Wilson KL |title=Nuclear assembly. |journal=Annu. Rev. Cell Dev. Biol. |volume=13 |issue= |pages= 669-95 |year= 1998 |pmid= 9442884 |doi= 10.1146/annurev.cellbio.13.1.669 }}
*{{cite journal | author=Helbling-Leclerc A, Bonne G, Schwartz K |title=Emery-Dreifuss muscular dystrophy. |journal=Eur. J. Hum. Genet. |volume=10 |issue= 3 |pages= 157-61 |year= 2002 |pmid= 11973618 |doi= 10.1038/sj.ejhg.5200744 }}
*{{cite journal | author=Holaska JM, Wilson KL |title=Multiple roles for emerin: implications for Emery-Dreifuss muscular dystrophy. |journal=The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology |volume=288 |issue= 7 |pages= 676-80 |year= 2006 |pmid= 16761279 |doi= 10.1002/ar.a.20334 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FXN... {November 7, 2007 2:49:23 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 2:49:55 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:50:15 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FXN_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ekg.
| PDB = {{PDB2|1ekg}}, {{PDB2|1ly7}}
| Name = Frataxin
| HGNCid = 3951
| Symbol = FXN
| AltSymbols =; FA; CyaY; FARR; FRDA; MGC57199; X25
| OMIM = 606829
| ECnumber =
| Homologene = 47908
| MGIid = 1096879
| GeneAtlas_image1 = PBB_GE_FXN_205565_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004428 |text = inositol or phosphatidylinositol kinase activity}} {{GNF_GO|id=GO:0005381 |text = iron ion transmembrane transporter activity}} {{GNF_GO|id=GO:0009055 |text = electron carrier activity}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006879 |text = cellular iron ion homeostasis}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0016192 |text = vesicle-mediated transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2395
| Hs_Ensembl = ENSG00000165060
| Hs_RefseqProtein = NP_000135
| Hs_RefseqmRNA = NM_000144
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 70839995
| Hs_GenLoc_end = 70878949
| Hs_Uniprot = Q16595
| Mm_EntrezGene = 14297
| Mm_Ensembl = ENSMUSG00000059363
| Mm_RefseqmRNA = XM_989030
| Mm_RefseqProtein = XP_994124
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 24328550
| Mm_GenLoc_end = 24347683
| Mm_Uniprot = Q3TV21
}}
}}
'''Frataxin''', also known as '''FXN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This nuclear gene encodes a mitochondrial protein which belongs to FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA results in Friedreich ataxia. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.<ref>{{cite web | title = Entrez Gene: FXN frataxin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2395| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GC... {November 7, 2007 2:50:15 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 2:50:45 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:50:59 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GC_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1j78.
| PDB = {{PDB2|1j78}}, {{PDB2|1j7e}}, {{PDB2|1kw2}}, {{PDB2|1kxp}}, {{PDB2|1lot}}, {{PDB2|1ma9}}
| Name = Group-specific component (vitamin D binding protein)
| HGNCid = 4187
| Symbol = GC
| AltSymbols =; DBP; DBP/GC; VDBG; VDBP
| OMIM = 139200
| ECnumber =
| Homologene = 486
| MGIid = 95669
| GeneAtlas_image1 = PBB_GE_GC_204965_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005386 |text = transmembrane transporter activity}} {{GNF_GO|id=GO:0005499 |text = vitamin D binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0051183 |text = vitamin transporter activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0042359 |text = vitamin D metabolic process}} {{GNF_GO|id=GO:0051180 |text = vitamin transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2638
| Hs_Ensembl = ENSG00000145321
| Hs_RefseqProtein = NP_000574
| Hs_RefseqmRNA = NM_000583
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 72826296
| Hs_GenLoc_end = 72868798
| Hs_Uniprot = P02774
| Mm_EntrezGene = 14473
| Mm_Ensembl = ENSMUSG00000035540
| Mm_RefseqmRNA = XM_904856
| Mm_RefseqProtein = XP_909949
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 90492721
| Mm_GenLoc_end = 90532964
| Mm_Uniprot = P21614
}}
}}
'''Group-specific component (vitamin D binding protein)''', also known as '''GC''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues.<ref>{{cite web | title = Entrez Gene: GC group-specific component (vitamin D binding protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2638| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GTF2H1... {November 7, 2007 2:52:37 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 2:53:26 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:53:39 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GTF2H1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1pfj.
| PDB = {{PDB2|1pfj}}, {{PDB2|2dii}}
| Name = General transcription factor IIH, polypeptide 1, 62kDa
| HGNCid = 4655
| Symbol = GTF2H1
| AltSymbols =; BTF2; TFIIH
| OMIM = 189972
| ECnumber =
| Homologene = 3885
| MGIid = 1277216
| GeneAtlas_image1 = PBB_GE_GTF2H1_202451_at_tn.png
| GeneAtlas_image2 = PBB_GE_GTF2H1_202453_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008353 |text = RNA polymerase subunit kinase activity}} {{GNF_GO|id=GO:0016251 |text = general RNA polymerase II transcription factor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005675 |text = holo TFIIH complex}}
| Process = {{GNF_GO|id=GO:0000079 |text = regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2965
| Hs_Ensembl = ENSG00000110768
| Hs_RefseqProtein = NP_005307
| Hs_RefseqmRNA = NM_005316
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 18300719
| Hs_GenLoc_end = 18345152
| Hs_Uniprot = P32780
| Mm_EntrezGene = 14884
| Mm_Ensembl = ENSMUSG00000006599
| Mm_RefseqmRNA = NM_008186
| Mm_RefseqProtein = NP_032212
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 46664145
| Mm_GenLoc_end = 46691839
| Mm_Uniprot = Q7TPY0
}}
}}
'''General transcription factor IIH, polypeptide 1, 62kDa''', also known as '''GTF2H1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Jeang KT |title=Tat, Tat-associated kinase, and transcription. |journal=J. Biomed. Sci. |volume=5 |issue= 1 |pages= 24-7 |year= 1998 |pmid= 9570510 |doi= }}
*{{cite journal | author=Yankulov K, Bentley D |title=Transcriptional control: Tat cofactors and transcriptional elongation. |journal=Curr. Biol. |volume=8 |issue= 13 |pages= R447-9 |year= 1998 |pmid= 9651670 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HEXB... {November 7, 2007 2:53:39 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 2:54:10 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:54:22 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HEXB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1nou.
| PDB = {{PDB2|1nou}}, {{PDB2|1now}}, {{PDB2|1np0}}, {{PDB2|1o7a}}, {{PDB2|2gjx}}, {{PDB2|2gk1}}
| Name = Hexosaminidase B (beta polypeptide)
| HGNCid = 4879
| Symbol = HEXB
| AltSymbols =; ENC-1AS
| OMIM = 606873
| ECnumber =
| Homologene = 437
| MGIid = 96074
| GeneAtlas_image1 = PBB_GE_HEXB_201944_at_tn.png
| Function = {{GNF_GO|id=GO:0004563 |text = beta-N-acetylhexosaminidase activity}} {{GNF_GO|id=GO:0016798 |text = hydrolase activity, acting on glycosyl bonds}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0043169 |text = cation binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0001669 |text = acrosome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006687 |text = glycosphingolipid metabolic process}} {{GNF_GO|id=GO:0006689 |text = ganglioside catabolic process}} {{GNF_GO|id=GO:0006874 |text = cellular calcium ion homeostasis}} {{GNF_GO|id=GO:0007040 |text = lysosome organization and biogenesis}} {{GNF_GO|id=GO:0007341 |text = penetration of zona pellucida}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0007626 |text = locomotory behavior}} {{GNF_GO|id=GO:0008049 |text = male courtship behavior}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0008654 |text = phospholipid biosynthetic process}} {{GNF_GO|id=GO:0009313 |text = oligosaccharide catabolic process}} {{GNF_GO|id=GO:0019915 |text = sequestering of lipid}} {{GNF_GO|id=GO:0019953 |text = sexual reproduction}} {{GNF_GO|id=GO:0030203 |text = glycosaminoglycan metabolic process}} {{GNF_GO|id=GO:0031323 |text = regulation of cellular metabolic process}} {{GNF_GO|id=GO:0042552 |text = myelination}} {{GNF_GO|id=GO:0044267 |text = cellular protein metabolic process}} {{GNF_GO|id=GO:0048157 |text = oogenesis}} {{GNF_GO|id=GO:0050885 |text = regulation of balance}} {{GNF_GO|id=GO:0050905 |text = neuromuscular process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3074
| Hs_Ensembl = ENSG00000049860
| Hs_RefseqProtein = NP_000512
| Hs_RefseqmRNA = NM_000521
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 74016725
| Hs_GenLoc_end = 74052869
| Hs_Uniprot = P07686
| Mm_EntrezGene = 15212
| Mm_Ensembl = ENSMUSG00000021665
| Mm_RefseqmRNA = NM_010422
| Mm_RefseqProtein = NP_034552
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 98277106
| Mm_GenLoc_end = 98298969
| Mm_Uniprot = Q3TXR9
}}
}}
'''Hexosaminidase B (beta polypeptide)''', also known as '''HEXB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II).<ref>{{cite web | title = Entrez Gene: HEXB hexosaminidase B (beta polypeptide)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3074| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Mahuran DJ |title=The biochemistry of HEXA and HEXB gene mutations causing GM2 gangliosidosis. |journal=Biochim. Biophys. Acta |volume=1096 |issue= 2 |pages= 87-94 |year= 1991 |pmid= 1825792 |doi= }}
*{{cite journal | author=Mahuran DJ |title=Biochemical consequences of mutations causing the GM2 gangliosidoses. |journal=Biochim. Biophys. Acta |volume=1455 |issue= 2-3 |pages= 105-38 |year= 1999 |pmid= 10571007 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HSD11B1... {November 7, 2007 2:54:22 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 2:54:57 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:55:19 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HSD11B1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1xu7.
| PDB = {{PDB2|1xu7}}, {{PDB2|1xu9}}, {{PDB2|2bel}}, {{PDB2|2ilt}}, {{PDB2|2irw}}
| Name = Hydroxysteroid (11-beta) dehydrogenase 1
| HGNCid = 5208
| Symbol = HSD11B1
| AltSymbols =; 11-DH; 11-beta-HSD1; HDL; HSD11; HSD11B; HSD11L; MGC13539
| OMIM = 600713
| ECnumber =
| Homologene = 68471
| MGIid = 103562
| GeneAtlas_image1 = PBB_GE_HSD11B1_205404_at_tn.png
| Function = {{GNF_GO|id=GO:0003845 |text = 11-beta-hydroxysteroid dehydrogenase activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005789 |text = endoplasmic reticulum membrane}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0008211 |text = glucocorticoid metabolic process}} {{GNF_GO|id=GO:0030324 |text = lung development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3290
| Hs_Ensembl = ENSG00000117594
| Hs_RefseqProtein = NP_005516
| Hs_RefseqmRNA = NM_005525
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 207926133
| Hs_GenLoc_end = 207974918
| Hs_Uniprot = P28845
| Mm_EntrezGene = 15483
| Mm_Ensembl = ENSMUSG00000016194
| Mm_RefseqmRNA = NM_001044751
| Mm_RefseqProtein = NP_001038216
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 194922413
| Mm_GenLoc_end = 194964769
| Mm_Uniprot = Q3TJI8
}}
}}
'''Hydroxysteroid (11-beta) dehydrogenase 1''', also known as '''HSD11B1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.<ref>{{cite web | title = Entrez Gene: HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3290| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=White PC, Mune T, Agarwal AK |title=11 beta-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. |journal=Endocr. Rev. |volume=18 |issue= 1 |pages= 135-56 |year= 1997 |pmid= 9034789 |doi= }}
*{{cite journal | author=Agarwal AK |title=Cortisol metabolism and visceral obesity: role of 11beta-hydroxysteroid dehydrogenase type I enzyme and reduced co-factor NADPH. |journal=Endocr. Res. |volume=29 |issue= 4 |pages= 411-8 |year= 2004 |pmid= 14682470 |doi= }}
*{{cite journal | author=Tomlinson JW, Walker EA, Bujalska IJ, ''et al.'' |title=11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response. |journal=Endocr. Rev. |volume=25 |issue= 5 |pages= 831-66 |year= 2005 |pmid= 15466942 |doi= 10.1210/er.2003-0031 }}
*{{cite journal | author=Odermatt A, Atanasov AG, Balazs Z, ''et al.'' |title=Why is 11beta-hydroxysteroid dehydrogenase type 1 facing the endoplasmic reticulum lumen? Physiological relevance of the membrane topology of 11beta-HSD1. |journal=Mol. Cell. Endocrinol. |volume=248 |issue= 1-2 |pages= 15-23 |year= 2006 |pmid= 16412558 |doi= 10.1016/j.mce.2005.11.040 }}
*{{cite journal | author=Wake DJ, Walker BR |title=Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 in obesity. |journal=Endocrine |volume=29 |issue= 1 |pages= 101-8 |year= 2006 |pmid= 16622297 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on IL2RB... {November 7, 2007 2:55:19 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 2:55:52 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:56:04 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_IL2RB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2b5i.
| PDB = {{PDB2|2b5i}}, {{PDB2|2erj}}
| Name = Interleukin 2 receptor, beta
| HGNCid = 6009
| Symbol = IL2RB
| AltSymbols =; CD122; P70-75
| OMIM = 146710
| ECnumber =
| Homologene = 47955
| MGIid = 96550
| GeneAtlas_image1 = PBB_GE_IL2RB_205291_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004896 |text = hematopoietin/interferon-class (D200-domain) cytokine receptor activity}} {{GNF_GO|id=GO:0004911 |text = interleukin-2 receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0019221 |text = cytokine and chemokine mediated signaling pathway}} {{GNF_GO|id=GO:0045885 |text = positive regulation of survival gene product activity}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3560
| Hs_Ensembl = ENSG00000100385
| Hs_RefseqProtein = NP_000869
| Hs_RefseqmRNA = NM_000878
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 22
| Hs_GenLoc_start = 35851824
| Hs_GenLoc_end = 35875908
| Hs_Uniprot = P14784
| Mm_EntrezGene = 16185
| Mm_Ensembl = ENSMUSG00000068227
| Mm_RefseqmRNA = NM_008368
| Mm_RefseqProtein = NP_032394
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 78307808
| Mm_GenLoc_end = 78322321
| Mm_Uniprot = Q3TEQ2
}}
}}
'''Interleukin 2 receptor, beta''', also known as '''IL2RB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.<ref>{{cite web | title = Entrez Gene: IL2RB interleukin 2 receptor, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3560| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ellery JM, Nicholls PJ |title=Alternate signalling pathways from the interleukin-2 receptor. |journal=Cytokine Growth Factor Rev. |volume=13 |issue= 1 |pages= 27-40 |year= 2002 |pmid= 11750878 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ITGA1... {November 7, 2007 2:56:04 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 2:56:17 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:56:29 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ITGA1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ck4.
| PDB = {{PDB2|1ck4}}, {{PDB2|1mhp}}, {{PDB2|1pt6}}, {{PDB2|1qc5}}, {{PDB2|1qcy}}, {{PDB2|2b2x}}
| Name = Integrin, alpha 1
| HGNCid = 6134
| Symbol = ITGA1
| AltSymbols =; CD49a; VLA1
| OMIM = 192968
| ECnumber =
| Homologene = 57137
| MGIid = 96599
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005518 |text = collagen binding}}
| Component = {{GNF_GO|id=GO:0008305 |text = integrin complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007160 |text = cell-matrix adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3672
| Hs_Ensembl =
| Hs_RefseqProtein = NP_852478
| Hs_RefseqmRNA = NM_181501
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 109700
| Mm_Ensembl = ENSMUSG00000042284
| Mm_RefseqmRNA = NM_001033228
| Mm_RefseqProtein = NP_001028400
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 116080957
| Mm_GenLoc_end = 116222842
| Mm_Uniprot = Q05DI0
}}
}}
'''Integrin, alpha 1''', also known as '''ITGA1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.<ref>{{cite web | title = Entrez Gene: ITGA1 integrin, alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3672| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Virtanen I, Korhonen M, Kariniemi AL, ''et al.'' |title=Integrins in human cells and tumors. |journal=Cell Differ. Dev. |volume=32 |issue= 3 |pages= 215-27 |year= 1991 |pmid= 2099238 |doi= }}
*{{cite journal | author=Plenz GA, Deng MC, Robenek H, Völker W |title=Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis. |journal=Atherosclerosis |volume=166 |issue= 1 |pages= 1-11 |year= 2003 |pmid= 12482545 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KPNA3... {November 7, 2007 2:56:29 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 2:57:25 PM PST}
- CREATED: Created new protein page: KPNA3 {November 7, 2007 2:57:32 PM PST}
- INFO: Beginning work on MAOB... {November 7, 2007 2:57:32 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 2:58:05 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 2:58:14 PM PST}
- CREATED: Created new protein page: MAOB {November 7, 2007 2:58:23 PM PST}
- INFO: Beginning work on ND4... {November 7, 2007 2:58:23 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 2:58:56 PM PST}
- CREATED: Created new protein page: ND4 {November 7, 2007 2:59:02 PM PST}
- INFO: Beginning work on NGFB... {November 7, 2007 2:59:02 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 2:59:35 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:59:53 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NGFB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bet.
| PDB = {{PDB2|1bet}}, {{PDB2|1btg}}, {{PDB2|1sg1}}, {{PDB2|1www}}, {{PDB2|2ifg}}
| Name = Nerve growth factor, beta polypeptide
| HGNCid = 7808
| Symbol = NGFB
| AltSymbols =; Beta-NGF; HSAN5; MGC161426; MGC161428; NGF
| OMIM = 162030
| ECnumber =
| Homologene = 1876
| MGIid = 97321
| GeneAtlas_image1 = PBB_GE_NGFB_206814_at_tn.png
| Function = {{GNF_GO|id=GO:0005057 |text = receptor signaling protein activity}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component =
| Process = {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007422 |text = peripheral nervous system development}} {{GNF_GO|id=GO:0019233 |text = sensory perception of pain}} {{GNF_GO|id=GO:0045664 |text = regulation of neuron differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4803
| Hs_Ensembl = ENSG00000134259
| Hs_RefseqProtein = NP_002497
| Hs_RefseqmRNA = NM_002506
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 115630060
| Hs_GenLoc_end = 115682380
| Hs_Uniprot = P01138
| Mm_EntrezGene = 18049
| Mm_Ensembl = ENSMUSG00000027859
| Mm_RefseqmRNA = NM_013609
| Mm_RefseqProtein = NP_038637
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 102598989
| Mm_GenLoc_end = 102650066
| Mm_Uniprot = Q6LDU8
}}
}}
'''Nerve growth factor, beta polypeptide''', also known as '''NGFB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.<ref>{{cite web | title = Entrez Gene: NGFB nerve growth factor, beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4803| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NPPA... {November 7, 2007 2:59:53 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:00:32 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Natriuretic peptide precursor A
| HGNCid = 7939
| Symbol = NPPA
| AltSymbols =; ANF; ANP; CDD-ANF; PND
| OMIM = 108780
| ECnumber =
| Homologene = 4498
| MGIid = 97367
| GeneAtlas_image1 = PBB_GE_NPPA_209957_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}} {{GNF_GO|id=GO:0050880 |text = regulation of blood vessel size}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4878
| Hs_Ensembl = ENSG00000175206
| Hs_RefseqProtein = NP_006163
| Hs_RefseqmRNA = NM_006172
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 11828353
| Hs_GenLoc_end = 11830989
| Hs_Uniprot = P01160
| Mm_EntrezGene = 230899
| Mm_Ensembl = ENSMUSG00000041616
| Mm_RefseqmRNA = NM_008725
| Mm_RefseqProtein = NP_032751
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 146844522
| Mm_GenLoc_end = 146845879
| Mm_Uniprot = O55083
}}
}}
'''Natriuretic peptide precursor A''', also known as '''NPPA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Vesely DL |title=Atrial natriuretic peptide prohormone gene expression: hormones and diseases that upregulate its expression. |journal=IUBMB Life |volume=53 |issue= 3 |pages= 153-9 |year= 2002 |pmid= 12102171 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PAEP... {November 7, 2007 3:00:32 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:02:47 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Progestagen-associated endometrial protein (placental protein 14, pregnancy-associated endometrial alpha-2-globulin, alpha uterine protein)
| HGNCid = 8573
| Symbol = PAEP
| AltSymbols =; GD; GdA; GdF; GdS; MGC138509; MGC142288; PAEG; PEP; PP14
| OMIM = 173310
| ECnumber =
| Homologene = 83207
| MGIid =
| GeneAtlas_image1 = PBB_GE_PAEP_206859_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005488 |text = binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5047
| Hs_Ensembl = ENSG00000122133
| Hs_RefseqProtein = NP_001018059
| Hs_RefseqmRNA = NM_001018049
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 137593423
| Hs_GenLoc_end = 137598622
| Hs_Uniprot = P09466
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Progestagen-associated endometrial protein (placental protein 14, pregnancy-associated endometrial alpha-2-globulin, alpha uterine protein)''', also known as '''PAEP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. A number of alternatively spliced transcript variants have been observed at this locus, but the full-length nature of only two, each encoding the same protein, has been determined.<ref>{{cite web | title = Entrez Gene: PAEP progestagen-associated endometrial protein (placental protein 14, pregnancy-associated endometrial alpha-2-globulin, alpha uterine protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5047| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Rutanen EM, Koistinen R, Seppälä M, ''et al.'' |title=Progesterone-associated proteins PP12 and PP14 in the human endometrium. |journal=J. Steroid Biochem. |volume=27 |issue= 1-3 |pages= 25-31 |year= 1988 |pmid= 3320533 |doi= }}
*{{cite journal | author=Seppälä M, Bohn H, Tatarinov Y |title=Glycodelins. |journal=Tumour Biol. |volume=19 |issue= 3 |pages= 213-20 |year= 1998 |pmid= 9591048 |doi= }}
*{{cite journal | author=Salier JP |title=Chromosomal location, exon/intron organization and evolution of lipocalin genes. |journal=Biochim. Biophys. Acta |volume=1482 |issue= 1-2 |pages= 25-34 |year= 2000 |pmid= 11058744 |doi= }}
*{{cite journal | author=Halttunen M, Kämäräinen M, Koistinen H |title=Glycodelin: a reproduction-related lipocalin. |journal=Biochim. Biophys. Acta |volume=1482 |issue= 1-2 |pages= 149-56 |year= 2000 |pmid= 11058757 |doi= }}
*{{cite journal | author=Seppälä M, Taylor RN, Koistinen H, ''et al.'' |title=Glycodelin: a major lipocalin protein of the reproductive axis with diverse actions in cell recognition and differentiation. |journal=Endocr. Rev. |volume=23 |issue= 4 |pages= 401-30 |year= 2003 |pmid= 12202458 |doi= }}
*{{cite journal | author=Seppälä M, Koistinen H, Koistinen R, ''et al.'' |title=Glycosylation related actions of glycodelin: gamete, cumulus cell, immune cell and clinical associations. |journal=Hum. Reprod. Update |volume=13 |issue= 3 |pages= 275-87 |year= 2007 |pmid= 17329396 |doi= 10.1093/humupd/dmm004 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PDIA3... {November 7, 2007 2:51:36 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 2:52:15 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:52:37 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PDIA3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2alb.
| PDB = {{PDB2|2alb}}, {{PDB2|2dmm}}, {{PDB2|2h8l}}
| Name = Protein disulfide isomerase family A, member 3
| HGNCid = 4606
| Symbol = PDIA3
| AltSymbols =; ERp57; ERp60; ERp61; GRP57; GRP58; HsT17083; P58; PI-PLC
| OMIM = 602046
| ECnumber =
| Homologene = 68454
| MGIid = 95834
| GeneAtlas_image1 = PBB_GE_PDIA3_208612_at_tn.png
| Function = {{GNF_GO|id=GO:0003756 |text = protein disulfide isomerase activity}} {{GNF_GO|id=GO:0004197 |text = cysteine-type endopeptidase activity}} {{GNF_GO|id=GO:0004629 |text = phospholipase C activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0009055 |text = electron carrier activity}} {{GNF_GO|id=GO:0015035 |text = protein disulfide oxidoreductase activity}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}}
| Process = {{GNF_GO|id=GO:0006606 |text = protein import into nucleus}} {{GNF_GO|id=GO:0006621 |text = protein retention in ER}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0043065 |text = positive regulation of apoptosis}} {{GNF_GO|id=GO:0045454 |text = cell redox homeostasis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2923
| Hs_Ensembl = ENSG00000167004
| Hs_RefseqProtein = NP_005304
| Hs_RefseqmRNA = NM_005313
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 41825882
| Hs_GenLoc_end = 41851035
| Hs_Uniprot = P30101
| Mm_EntrezGene = 14827
| Mm_Ensembl = ENSMUSG00000027248
| Mm_RefseqmRNA = NM_007952
| Mm_RefseqProtein = NP_031978
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 121105386
| Mm_GenLoc_end = 121129419
| Mm_Uniprot = Q3TEI9
}}
}}
'''Protein disulfide isomerase family A, member 3''', also known as '''PDIA3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates.<ref>{{cite web | title = Entrez Gene: PDIA3 protein disulfide isomerase family A, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2923| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Garbi N, Hämmerling G, Tanaka S |title=Interaction of ERp57 and tapasin in the generation of MHC class I-peptide complexes. |journal=Curr. Opin. Immunol. |volume=19 |issue= 1 |pages= 99-105 |year= 2007 |pmid= 17150345 |doi= 10.1016/j.coi.2006.11.013 }}
*{{cite journal | author=Khanal RC, Nemere I |title=The ERp57/GRp58/1,25D3-MARRS receptor: multiple functional roles in diverse cell systems. |journal=Curr. Med. Chem. |volume=14 |issue= 10 |pages= 1087-93 |year= 2007 |pmid= 17456022 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SERPINF1... {November 7, 2007 3:02:47 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 3:03:21 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:03:37 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SERPINF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1imv.
| PDB = {{PDB2|1imv}}
| Name = Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
| HGNCid = 8824
| Symbol = SERPINF1
| AltSymbols =; EPC-1; PEDF; PIG35
| OMIM = 172860
| ECnumber =
| Homologene = 1965
| MGIid = 108080
| GeneAtlas_image1 = PBB_GE_SERPINF1_202283_at_tn.png
| Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0016525 |text = negative regulation of angiogenesis}} {{GNF_GO|id=GO:0050769 |text = positive regulation of neurogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5176
| Hs_Ensembl = ENSG00000132386
| Hs_RefseqProtein = NP_002606
| Hs_RefseqmRNA = NM_002615
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 1612003
| Hs_GenLoc_end = 1627618
| Hs_Uniprot = P36955
| Mm_EntrezGene = 20317
| Mm_Ensembl = ENSMUSG00000000753
| Mm_RefseqmRNA = NM_011340
| Mm_RefseqProtein = NP_035470
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 75225964
| Mm_GenLoc_end = 75238728
| Mm_Uniprot = Q5ND38
}}
}}
'''Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1''', also known as '''SERPINF1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tong JP, Yao YF |title=Contribution of VEGF and PEDF to choroidal angiogenesis: a need for balanced expressions. |journal=Clin. Biochem. |volume=39 |issue= 3 |pages= 267-76 |year= 2006 |pmid= 16409998 |doi= 10.1016/j.clinbiochem.2005.11.013 }}
}}
{{refend}}
{{protein-stub}}
end log.
