ND4

From Wikipedia, the free encyclopedia

NADH dehydrogenase subunit 4

Identifiers

ND4; MTND4

External IDs

Gene ontology
Molecular Function:	• NADH dehydrogenase (ubiquinone) activity • oxidoreductase activity
Cellular Component:	• mitochondrion • mitochondrial respiratory chain complex I
Biological Process:	• mitochondrial electron transport, NADH to ubiquinone • ATP synthesis coupled electron transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

n/a (mRNA)
NP_536852 (protein)

n/a (mRNA)
NP_904337 (protein)

Location

Chr MT: 0.01 - 0.01 Mb

Pubmed search

[1]

[2]

NADH dehydrogenase subunit 4, also known as ND4, is a human gene.

[edit] Further reading

Torroni A, Achilli A, Macaulay V, et al. (2006). "Harvesting the fruit of the human mtDNA tree.". Trends Genet. 22 (6): 339–45. doi:10.1016/j.tig.2006.04.001. PMID 16678300.
Lertrit P, Noer AS, Jean-Francois MJ, et al. (1992). "A new disease-related mutation for mitochondrial encephalopathy lactic acidosis and strokelike episodes (MELAS) syndrome affects the ND4 subunit of the respiratory complex I.". Am. J. Hum. Genet. 51 (3): 457–68. PMID 1323207.
Lu X, Walker T, MacManus JP, Seligy VL (1992). "Differentiation of HT-29 human colonic adenocarcinoma cells correlates with increased expression of mitochondrial RNA: effects of trehalose on cell growth and maturation.". Cancer Res. 52 (13): 3718–25. PMID 1377597.
Marzuki S, Noer AS, Lertrit P, et al. (1992). "Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.". Hum. Genet. 88 (2): 139–45. PMID 1757091.
Majander A, Huoponen K, Savontaus ML, et al. (1992). "Electron transfer properties of NADH:ubiquinone reductase in the ND1/3460 and the ND4/11778 mutations of the Leber hereditary optic neuroretinopathy (LHON).". FEBS Lett. 292 (1-2): 289–92. PMID 1959619.
Kormann BA, Schuster H, Berninger TA, Leo-Kottler B (1992). "Detection of the G to A mitochondrial DNA mutation at position 11778 in German families with Leber's hereditary optic neuropathy.". Hum. Genet. 88 (1): 98–100. PMID 1959931.
Moraes CT, Andreetta F, Bonilla E, et al. (1991). "Replication-competent human mitochondrial DNA lacking the heavy-strand promoter region.". Mol. Cell. Biol. 11 (3): 1631–7. PMID 1996112.
Wallace DC, Singh G, Lott MT, et al. (1989). "Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy.". Science 242 (4884): 1427–30. PMID 3201231.
Chomyn A, Cleeter MW, Ragan CI, et al. (1986). "URF6, last unidentified reading frame of human mtDNA, codes for an NADH dehydrogenase subunit.". Science 234 (4776): 614–8. PMID 3764430.
Chomyn A, Mariottini P, Cleeter MW, et al. (1985). "Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.". Nature 314 (6012): 592–7. PMID 3921850.
Brown WM, Prager EM, Wang A, Wilson AC (1982). "Mitochondrial DNA sequences of primates: tempo and mode of evolution.". J. Mol. Evol. 18 (4): 225–39. PMID 6284948.
Anderson S, Bankier AT, Barrell BG, et al. (1981). "Sequence and organization of the human mitochondrial genome.". Nature 290 (5806): 457–65. PMID 7219534.
Montoya J, Ojala D, Attardi G (1981). "Distinctive features of the 5'-terminal sequences of the human mitochondrial mRNAs.". Nature 290 (5806): 465–70. PMID 7219535.
De Vries DD, Went LN, Bruyn GW, et al. (1996). "Genetic and biochemical impairment of mitochondrial complex I activity in a family with Leber hereditary optic neuropathy and hereditary spastic dystonia.". Am. J. Hum. Genet. 58 (4): 703–11. PMID 8644732.
Sudoyo H, Sitepu M, Malik S, et al. (1999). "Leber's hereditary optic neuropathy in Indonesia: two families with the mtDNA 11778G>A and 14484T>C mutations.". Hum. Mutat. Suppl 1: S271–4. PMID 9452107.
Andrews RM, Kubacka I, Chinnery PF, et al. (1999). "Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA.". Nat. Genet. 23 (2): 147. doi:10.1038/13779. PMID 10508508.
Ingman M, Kaessmann H, Pääbo S, Gyllensten U (2001). "Mitochondrial genome variation and the origin of modern humans.". Nature 408 (6813): 708–13. doi:10.1038/35047064. PMID 11130070.
Finnilä S, Lehtonen MS, Majamaa K (2001). "Phylogenetic network for European mtDNA.". Am. J. Hum. Genet. 68 (6): 1475–84. PMID 11349229.
Maca-Meyer N, González AM, Larruga JM, et al. (2003). "Major genomic mitochondrial lineages delineate early human expansions.". BMC Genet. 2: 13. PMID 11553319.
Herrnstadt C, Elson JL, Fahy E, et al. (2002). "Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups.". Am. J. Hum. Genet. 70 (5): 1152–71. PMID 11938495.