Talk:Prostate specific antigen

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[edit] PSA not raised by digital rectal exam

I quote the latest edition of Kumar and Clark (Clinical Medicine 6th edition 2005, p. 685) "It is a myth the elevated levels occur as a result of rectal examination."

--Kleedham 08:31, 11 October 2006 (UTC)

The above quote does NOT appear in the cited book.

Studies have found small transient increases (that are not usually clinically significant) in total, complexed, and free PSA after DREs.

Kalthree (talk) 02:41, 28 November 2007 (UTC)

Kumar and Clark, 6th edition, does state it is a myth as the first comment stated, on page 2005. The stated source (^ Crawford ED, Schutz MJ, Clejan S, Drago J, Resnick MI, Chodak GW, Gomella LG, Austenfeld M, Stone NN, Miles BJ, et al (1992). "The effect of digital rectal examination on prostate-specific antigen levels". JAMA 267 (16): 2227-8. PMID 1372943.) does find a link but only in patients with already raised levels and as such it is clinically insignificant as it states. As such, digital rectal exam will not aid in giving a false positive. --Quetzaquotal (talk) 14:26, 27 April 2008 (UTC)

I attempted an edit to reflect the information from the articles cited more accurately. Regards, Ryanjo (talk) 19:02, 27 April 2008 (UTC)

[edit] Obesity

JAMA this week: obesity may reduce actual PSA level and could account for false-negatives. JFW | T@lk 08:35, 21 November 2007 (UTC)

I added this information & reference to the article Ryanjo (talk) 19:28, 27 April 2008 (UTC)