Protein-disulfide reductase

From Wikipedia, the free encyclopedia

In enzymology, a protein-disulfide reductase (EC 1.8.1.8) is an enzyme that catalyzes the chemical reaction

protein dithiol + NAD(P)+ protein disulfide + NAD(P)H + H⁺

The 3 substrates of this enzyme are protein dithiol, NAD⁺, and NADP⁺, whereas its 4 products are protein disulfide, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is protein-dithiol:NAD(P)+ oxidoreductase. Other names in common use include protein disulphide reductase, insulin-glutathione transhydrogenase, disulfide reductase, and NAD(P)H2:protein-disulfide oxidoreductase.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1UC7, 1VRS, 1Z5Y, 2FWE, 2FWF, 2FWG, 2FWH, and 2PPT.

[edit] References

• IUBMB entry for 1.8.1.8
• BRENDA references for 1.8.1.8 (Recommended.)
• PubMed references for 1.8.1.8
• PubMed Central references for 1.8.1.8
• Google Scholar references for 1.8.1.8
• HATCH MD, TURNER JF (1960). "A protein disulphide reductase from pea seeds". Biochem. J. 76: 556–62. PMID 13712218. 

[edit] External links

The CAS registry number for this enzyme class is 9029-19-0.

• IUBMB entry for 1.8.1.8

• KEGG entry for 1.8.1.8

• BRENDA entry for 1.8.1.8

• NiceZyme view of 1.8.1.8

• EC2PDB: PDB structures for 1.8.1.8

• PRIAM entry for 1.8.1.8

• PUMA2 entry for 1.8.1.8

• IntEnz: Integrated Enzyme entry for 1.8.1.8

• MetaCyc entry for 1.8.1.8

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047134: protein-disulfide reductase

• AMIGO entry for GO code 0047134: protein-disulfide reductase