Precorrin-6A reductase

From Wikipedia, the free encyclopedia

In enzymology, a precorrin-6A reductase (EC 1.3.1.54) is an enzyme that catalyzes the chemical reaction

precorrin-6B + NADP⁺ precorrin-6A + NADPH + H⁺

Thus, the two substrates of this enzyme are precorrin 6B and NADP⁺, whereas its 3 products are precorrin 6A, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is precorrin-6B:NADP+ oxidoreductase. Other names in common use include precorrin-6X reductase, and precorrin-6Y:NADP+ oxidoreductase. This enzyme participates in porphyrin and chlorophyll metabolism.

[edit] References

• IUBMB entry for 1.3.1.54
• BRENDA references for 1.3.1.54 (Recommended.)
• PubMed references for 1.3.1.54
• PubMed Central references for 1.3.1.54
• Google Scholar references for 1.3.1.54
• Blanche F, Thibaut D, Famechon A, Debussche L, Cameron B, Crouzet J (1992). "Precorrin-6x reductase from Pseudomonas denitrificans: purification and characterization of the enzyme and identification of the structural gene". J. Bacteriol. 174: 1036–42. PMID 1732193. 
• Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (2002). "The biosynthesis of adenosylcobalamin (vitamin B12)". Nat. Prod. Rep. 19: 390–412. doi:10.1039/b108967f. PMID 12195810. 

[edit] External links

The CAS registry number for this enzyme class is 137672-84-5.

• IUBMB entry for 1.3.1.54

• KEGG entry for 1.3.1.54

• BRENDA entry for 1.3.1.54

• NiceZyme view of 1.3.1.54

• EC2PDB: PDB structures for 1.3.1.54

• PRIAM entry for 1.3.1.54

• PUMA2 entry for 1.3.1.54

• IntEnz: Integrated Enzyme entry for 1.3.1.54

• MetaCyc entry for 1.3.1.54

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0016994: precorrin-6A reductase

• AMIGO entry for GO code 0016994: precorrin-6A reductase