Phthalate 4,5-cis-dihydrodiol dehydrogenase

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In enzymology, a phthalate 4,5-cis-dihydrodiol dehydrogenase (EC 1.3.1.64) is an enzyme that catalyzes the chemical reaction

cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD⁺ 4,5-dihydroxyphthalate + NADH + H⁺

Thus, the two substrates of this enzyme are cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate and NAD⁺, whereas its 3 products are 4,5-dihydroxyphthalate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate:NAD+ oxidoreductase. This enzyme participates in 2,4-dichlorobenzoate degradation.

[edit] References

• IUBMB entry for 1.3.1.64
• BRENDA references for 1.3.1.64 (Recommended.)
• PubMed references for 1.3.1.64
• PubMed Central references for 1.3.1.64
• Google Scholar references for 1.3.1.64
• Batie CJ, LaHaie E, Ballou DP (1987). "Purification and characterization of phthalate oxygenase and phthalate oxygenase reductase from Pseudomonas cepacia". J. Biol. Chem. 262: 1510–8. PMID 3805038. 

[edit] External links

• IUBMB entry for 1.3.1.64

• KEGG entry for 1.3.1.64

• BRENDA entry for 1.3.1.64

• NiceZyme view of 1.3.1.64

• EC2PDB: PDB structures for 1.3.1.64

• PRIAM entry for 1.3.1.64

• PUMA2 entry for 1.3.1.64

• IntEnz: Integrated Enzyme entry for 1.3.1.64

• MetaCyc entry for 1.3.1.64

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018517: phthalate 4,5-cis-dihydrodiol dehydrogenase

• AMIGO entry for GO code 0018517: phthalate 4,5-cis-dihydrodiol dehydrogenase