Phosphonate dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a phosphonate dehydrogenase (EC 1.20.1.1) is an enzyme that catalyzes the chemical reaction

phosphonate + NAD⁺ + H₂O phosphate + NADH + H⁺

The 3 substrates of this enzyme are phosphonate, NAD⁺, and H₂O, whereas its 3 products are phosphate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on phosphorus or arsenic in donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is phosphonate:NAD+ oxidoreductase. Other names in common use include NAD:phosphite oxidoreductase, and phosphite dehydrogenase.

[edit] References

• IUBMB entry for 1.20.1.1
• BRENDA references for 1.20.1.1 (Recommended.)
• PubMed references for 1.20.1.1
• PubMed Central references for 1.20.1.1
• Google Scholar references for 1.20.1.1
• Costas AM, White AK, Metcalf WW (2001). "Purification and characterization of a novel phosphorus-oxidizing enzyme from Pseudomonas stutzeri WM88". J. Biol. Chem. 276: 17429–36. doi:10.1074/jbc.M011764200. PMID 11278981. 
• Vrtis JM, White AK, Metcalf WW, van der Donk WA (2001). "Phosphite dehydrogenase: an unusual phosphoryl transfer reaction". J. Am. Chem. Soc. 123: 2672–3. doi:10.1021/ja004301k. PMID 11456941. 

[edit] External links

• IUBMB entry for 1.20.1.1

• KEGG entry for 1.20.1.1

• BRENDA entry for 1.20.1.1

• NiceZyme view of 1.20.1.1

• EC2PDB: PDB structures for 1.20.1.1

• PRIAM entry for 1.20.1.1

• PUMA2 entry for 1.20.1.1

• IntEnz: Integrated Enzyme entry for 1.20.1.1

• MetaCyc entry for 1.20.1.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050609: phosphonate dehydrogenase

• AMIGO entry for GO code 0050609: phosphonate dehydrogenase