Phosphogluconate 2-dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a phosphogluconate 2-dehydrogenase (EC 1.1.1.43) is an enzyme that catalyzes the chemical reaction

6-phospho-D-gluconate + NAD(P)+ 6-phospho-2-dehydro-D-gluconate + NAD(P)H + H⁺

The 3 substrates of this enzyme are 6-phospho-D-gluconic acid, NAD⁺, and NADP⁺, whereas its 4 products are 6-phospho-2-dehydro-D-gluconic acid, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase. Other names in common use include 6-phosphogluconic dehydrogenase, phosphogluconate dehydrogenase, gluconate 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase (NAD+), and 2-keto-6-phosphogluconate reductase. This enzyme participates in pentose phosphate pathway and glutathione metabolism.

[edit] References

• IUBMB entry for 1.1.1.43
• BRENDA references for 1.1.1.43 (Recommended.)
• PubMed references for 1.1.1.43
• PubMed Central references for 1.1.1.43
• Google Scholar references for 1.1.1.43
• Frampton EW, Wood WA (1961). "Carbohydrate oxidation by Pseudomonas fluorescens VI. Conversion of 2-keto-6-phosphogluconate to pyruvate". J. Biol. Chem. 236: 2571–2577. PMID 13894458. 

[edit] External links

The CAS registry number for this enzyme class is 9001-82-5.

• IUBMB entry for 1.1.1.43

• KEGG entry for 1.1.1.43

• BRENDA entry for 1.1.1.43

• NiceZyme view of 1.1.1.43

• EC2PDB: PDB structures for 1.1.1.43

• PRIAM entry for 1.1.1.43

• PUMA2 entry for 1.1.1.43

• IntEnz: Integrated Enzyme entry for 1.1.1.43

• MetaCyc entry for 1.1.1.43

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008114: phosphogluconate 2-dehydrogenase

• AMIGO entry for GO code 0008114: phosphogluconate 2-dehydrogenase