Phosphatidylcholine desaturase

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In enzymology, a phosphatidylcholine desaturase (EC 1.3.1.35) is an enzyme that catalyzes the chemical reaction

1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + NAD⁺ $\rightleftharpoons$ 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + NADH + H⁺

Thus, the two substrates of this enzyme are 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine and NAD⁺, whereas its 3 products are 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine:NAD+ Delta12-oxidoreductase. Other names in common use include oleate desaturase, linoleate synthase, oleoyl-CoA desaturase, and oleoylphosphatidylcholine desaturase.

[edit] References

IUBMB entry for 1.3.1.35
BRENDA references for 1.3.1.35 (Recommended.)
PubMed references for 1.3.1.35
PubMed Central references for 1.3.1.35
Google Scholar references for 1.3.1.35
Pugh EL, Kates M (1975). "Characterization of a membrane-bound phospholipid desaturase system of candida lipolytica". Biochim. Biophys. Acta. 380: 442–53. PMID 166662.
Slack CR, Roughan PG, Browse J (1979). "Evidence for an oleoyl phosphatidylcholine desaturase in microsomal preparations from cotyledons of safflower (Carthamus tinctorius) seed". Biochem. J. 179: 649–56. PMID 475773.
Stymne S, Appelqvist LA (1978). "The biosynthesis of linoleate from oleoyl-CoA via oleoyl-phosphatidylcholine in microsomes of developing safflower seeds". Eur. J. Biochem. 90: 223–9. PMID 710426.