Phloroisovalerophenone synthase

From Wikipedia, the free encyclopedia

In enzymology, a phloroisovalerophenone synthase (EC 2.3.1.156) is an enzyme that catalyzes the chemical reaction

isovaleryl-CoA + 3 malonyl-CoA 4 CoASH + 3 CO₂ + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one

Thus, the two substrates of this enzyme are isovaleryl-CoA and malonyl-CoA, whereas its 3 products are CoASH, CO₂, and 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is isovaleryl-CoA:malonyl-CoA acyltransferase. Other names in common use include valerophenone synthase, and 3-methyl-1-(trihydroxyphenyl)butan-1-one synthase.

[edit] References

• IUBMB entry for 2.3.1.156
• BRENDA references for 2.3.1.156 (Recommended.)
• PubMed references for 2.3.1.156
• PubMed Central references for 2.3.1.156
• Google Scholar references for 2.3.1.156
• Verpoorte R (1997). "Enzymes from the biosynthesis of hop alpha and beta acids". Proc. 26th Congr. Eur. Brew. Conv.: 215–221. 
• G, Verpoorte R and Schroder J (1998). "4-Hydroxy-2-pyrone formation by chalcone and stilbene synthase with nonphysiological substrates". Phytochemistry 49: 1945–1951. doi:10.1016/S0031-9422(98)00346-X. 

[edit] External links

• IUBMB entry for 2.3.1.156

• KEGG entry for 2.3.1.156

• BRENDA entry for 2.3.1.156

• NiceZyme view of 2.3.1.156

• EC2PDB: PDB structures for 2.3.1.156

• PRIAM entry for 2.3.1.156

• PUMA2 entry for 2.3.1.156

• IntEnz: Integrated Enzyme entry for 2.3.1.156

• MetaCyc entry for 2.3.1.156

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050634: phloroisovalerophenone synthase

• AMIGO entry for GO code 0050634: phloroisovalerophenone synthase