Phenylacetaldehyde dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a phenylacetaldehyde dehydrogenase (EC 1.2.1.39) is an enzyme that catalyzes the chemical reaction

phenylacetaldehyde + NAD⁺ + H₂O phenylacetate + NADH + 2 H⁺

The 3 substrates of this enzyme are phenylacetaldehyde, NAD⁺, and H₂O, whereas its 3 products are phenylacetate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is phenylacetaldehyde:NAD+ oxidoreductase. This enzyme participates in phenylalanine metabolism and styrene degradation.

[edit] References

• IUBMB entry for 1.2.1.39
• BRENDA references for 1.2.1.39 (Recommended.)
• PubMed references for 1.2.1.39
• PubMed Central references for 1.2.1.39
• Google Scholar references for 1.2.1.39
• Fujioka M, Morino Y and Wada H (1970). "Metabolism of phenylalanine (Achromobacter eurydice). III Phenylacetaldehyde dehydrogenase". Methods Enzymol. 17A: 593–596. 

[edit] External links

The CAS registry number for this enzyme class is 58943-37-6.

• IUBMB entry for 1.2.1.39

• KEGG entry for 1.2.1.39

• BRENDA entry for 1.2.1.39

• NiceZyme view of 1.2.1.39

• EC2PDB: PDB structures for 1.2.1.39

• PRIAM entry for 1.2.1.39

• PUMA2 entry for 1.2.1.39

• IntEnz: Integrated Enzyme entry for 1.2.1.39

• MetaCyc entry for 1.2.1.39

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008957: phenylacetaldehyde dehydrogenase

• AMIGO entry for GO code 0008957: phenylacetaldehyde dehydrogenase